{"created":"2023-07-27T06:57:01.009063+00:00","id":54030,"links":{},"metadata":{"_buckets":{"deposit":"992151ec-5aab-49a8-aa0c-d9b677de7e3b"},"_deposit":{"created_by":18,"id":"54030","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"54030"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00054030","sets":["2812:2813:2846"]},"author_link":["48987","30802"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1986 – 1987","bibliographic_titles":[{"bibliographic_title":"昭和62(1987)年度 科学研究費補助金 がん特別研究 研究概要"},{"bibliographic_title":"1987 Research Project Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1.水溶媒中でミセルを形成するように胆汁酸を脱離基としたDACHPのミセル形成型白金錯体を合成し,その抗腫瘍活性を検討した. これられ錯体は全身投与可能な脂溶性錯体であり, マウス白血病L1210やマウス悪性黒色腫瘍B16メラノーマに対して,in vivoで著明な効果を示した. 脱離基分子上の水酸基の数,位置,配置が油層への溶解度,ミラル形成,抗腫瘍活性等に大きく影響を与えることを明らかにした.\n2.2′ーdeoxyー2′ーmethylideue cytidine(DMDC) の抗腫瘍活性を更に検討した. その結果, マウス白血病以外にヒト由未白血病細胞やヒト由未カルチノーマに対しても効果が見いだされ, DMDCが白血病のみならずヒト固型腫瘍にも有効であることが分った. 又, このDMDCは鶏卵法でもヒト肺癌に制癌効果を示した. 作用機作の解明を含めた広範な前臨床実験を目下実施中である.\n3.1,4ーbutanediol diー2,2,2ーtrifluoraethanesulfonate(BFS) と1,4ーbutanedioldiisethionate(BIT)を用いて,chronic myeloid leukemia(CML)に対する治療薬としての特性を既知制癌剤のbusulfanと比較検討した. その結果,busulfanは骨髓抑制以外の致死的毒作用を有し,しかもmgeloid系への選択毒性が,BFS,BITに比べて小さい事が判明した. 從って,BFS及びBITは,毒性面からも,またmyeloid選択毒性面から見てもbusulfanに優るCML治療薬となる可能性が強く示唆された.\n4.臨床応用可能な分化誘導物質をめざして,多数の新規核酸関連合成化合物を検討の結果,2,4ーdiethylー7,7,8,8ーtetramethylーcisー2,4ーdiazabicyclo〔4.2,0〕Octaneー3,5ーdioneがヒト前髓球性白血病細胞(HLー60)に対して強い分化誘導効果と増殖抑制効果を示すことを見出した. また,この新規分化誘導物質に,抗白血病剤(daunomycin)やビタミンA誘導体と併用すると,相乘的に作用が増強されることを見出した.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:62010033, 研究期間(年度):1986 – 1987","subitem_description_type":"Other"},{"subitem_description":"出典：「新しい合成制癌剤の研究」研究成果報告書　課題番号62010033\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-62010033/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00060308","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=90109976"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=90109976","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-62010033/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-62010033/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-06-07"}],"displaytype":"detail","filename":"CA-PR-SASAKI-T-kaken 2016-1987-2p.pdf","filesize":[{"value":"179.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SASAKI-T-kaken 2016-1987-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/54030/files/CA-PR-SASAKI-T-kaken 2016-1987-2p.pdf"},"version_id":"f033423c-d634-47ec-a5fc-577997562cac"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新しい合成制癌剤の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新しい合成制癌剤の研究"}]},"item_type_id":"9","owner":"18","path":["2846"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-06-07"},"publish_date":"2021-06-07","publish_status":"0","recid":"54030","relation_version_is_last":true,"title":["新しい合成制癌剤の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:54:25.556287+00:00"}