{"created":"2023-07-27T06:57:14.280926+00:00","id":54333,"links":{},"metadata":{"_buckets":{"deposit":"bd24a382-e386-4a61-b3e6-b35a83ab2be7"},"_deposit":{"created_by":18,"id":"54333","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"54333"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00054333","sets":["2812:2813:3929"]},"author_link":["52625","73985"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3p.","bibliographicVolumeNumber":"2019","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 奨励研究 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"自閉スペクトラム症患者へ施した点鼻オキシトシン(OT)が脳関門を通過することを証明した。この研究で我々は新たに、オキシトシン結合因子C4aはOT輸送担体Receptor for Advanced Glycation End-products(RAGE)とも結合することを見出した。\n本課題では、本来は古典的経路で活性化され、炎症に関わるC4aが、妊娠や出産というOTが関与するライフステージにおいて、C4aの関連を自閉症モデルと野生型マウスを用いて研究した。結果、妊娠期においてOTとC4aの血中濃度の高低変動が逆転していることを見出した。これは炎症状態が出生後のASD症状に影響する可能性を示唆する。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19H00388, 研究期間(年度):2019","subitem_description_type":"Other"},{"subitem_description":"出典：「マウスの生育過程・妊娠・出産期のオキシトシンに結合する担体C4aの生理的役割の検証」研究成果報告書　課題番号19H00388\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19H00388/19H00388seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学子どものこころの発達研究センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00060609","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H00388/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H00388/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19H00388/19H00388seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19H00388/19H00388seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-06-18"}],"displaytype":"detail","filename":"CH-PR-YUHI-T-kaken 2020-3p.pdf","filesize":[{"value":"313.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CH-PR-YUHI-T-kaken 2020-3p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/54333/files/CH-PR-YUHI-T-kaken 2020-3p.pdf"},"version_id":"142c7a35-8d0b-459c-ae89-ebfeb858aced"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マウスの生育過程・妊娠・出産期のオキシトシンに結合する担体C4aの生理的役割の検証","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウスの生育過程・妊娠・出産期のオキシトシンに結合する担体C4aの生理的役割の検証"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-06-18"},"publish_date":"2021-06-18","publish_status":"0","recid":"54333","relation_version_is_last":true,"title":["マウスの生育過程・妊娠・出産期のオキシトシンに結合する担体C4aの生理的役割の検証"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:10:35.916224+00:00"}