{"created":"2023-07-27T06:57:33.794406+00:00","id":54803,"links":{},"metadata":{"_buckets":{"deposit":"5bae18fa-f707-4f8d-a276-2f4e3303ec16"},"_deposit":{"created_by":18,"id":"54803","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"54803"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00054803","sets":["2812:2813:2828"]},"author_link":["30555","20582"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"2003 – 2005","bibliographic_titles":[{"bibliographic_title":"平成17(2005)年度 科学研究費補助金 若手研究(B) 研究概要"},{"bibliographic_title":"2005 Research Project Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"IL-10プロモーター領域の1塩基多型(SNP)としてこれまで報告され,本研究の対象として考えていた-592(C/A), -819(C/T), -1082(A/G), -1330(G/A), -2763(C/A), -2849(G/A), -3575(T/A)のうち,引き続き-1082(A/G)に着目して検討した.\n上咽頭癌患者30名および健常者30名において,書面による同意を得たのちに,末梢血よりゲノムDNAを抽出した.過年度の結果よりTaqManPCR法を用いた方法ではなく,ダイレクトシークエンス法を用いた検出法を利用した.-1082SNPを検出するためのプログラムに一部変更があり,過年度に施行したものも含めて再検討した.\nその結果,-1082SNPに関しては上咽頭癌患者と健常人の間に特に差を認めなかった.したがって上咽頭癌に特異的なSNPは-1082(A/G)に関しては存在しないと思われた.したがって,当初予定していた-1082(A/G)に関するルシフェラーゼアッセイによる転写活性化能の違いの検討は施行しなかった.\n以上の結果から,-1082(A/G)SNPは上咽頭がん発がんに関与しないものと推測された.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15790929, 研究期間(年度):2003 – 2005","subitem_description_type":"Other"},{"subitem_description":"出典：「インターロイキン10プロモーター多型と上咽頭がん発がん,EBウイルスとの関連」研究成果報告書　課題番号15790929\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15790929/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00061079","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=20345622"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=20345622","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15790929/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15790929/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-12-02"}],"displaytype":"detail","filename":"ME-PR-MURONO-S-kaken 2016-2p.pdf","filesize":[{"value":"119.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MURONO-S-kaken 2016-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/54803/files/ME-PR-MURONO-S-kaken 2016-2p.pdf"},"version_id":"acfe3722-9f29-4ea0-bc46-7ba3573c251a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"インターロイキン10プロモーター多型と上咽頭がん発がん,EBウイルスとの関連","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"インターロイキン10プロモーター多型と上咽頭がん発がん,EBウイルスとの関連"}]},"item_type_id":"9","owner":"18","path":["2828"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-12-02"},"publish_date":"2021-12-02","publish_status":"0","recid":"54803","relation_version_is_last":true,"title":["インターロイキン10プロモーター多型と上咽頭がん発がん,EBウイルスとの関連"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:07:48.434469+00:00"}