@article{oai:kanazawa-u.repo.nii.ac.jp:00055261,
 author = {向田, 直史 and 馬場, 智久 and 中本, 安成 and Mukaida, Naofumi and Nosaka, Takuto and Nakamoto, Yasunari and Baba, Tomohisa},
 issue = {1},
 journal = {International Journal of Molecular Sciences},
 month = {Jan},
 note = {Metastasis is responsible for most of the cancer-associated deaths and proceeds through multiple steps. Several lines of evidence have established an indispensable involvement of macrophages present at the primary tumor sites in various steps of metastasis, from primary tumor growth to its intravasation into circulation. The lungs encompass a large, dense vascular area and, therefore, are vulnerable to metastasis, particularly, hematogenous ones arising from various types of neoplasms. Lung tissues constitutively contain several types of tissue-resident macrophages and circulating monocytes to counteract potentially harmful exogenous materials, which directly reach through the airway. Recent advances have provided an insight into the ontogenetic, phenotypic, and functional heterogeneity of these lung macrophage and monocyte populations, under resting and inflammatory conditions. In this review, we discuss the ontogeny, trafficking dynamics, and functions of these pulmonary macrophages and monocytes and their potential roles in lung metastasis and measures to combat lung metastasis by targeting these populations. © 2018 by the authors. Licensee MDPI, Basel, Switzerland., Acknowledgments: This work is supported partially by Research Program on the Innovative Development and Application for New Drugs for Hepatitis B (17fk0310116h0001) from the Japan Agency for Medical Research and Development (AMED) (N.M., Y.N.) and Extramural Collaborative Research Grant of Cancer Research Institute, Kanazawa University (N.M., Y.N.)., 金沢大学がん進展制御研究所},
 title = {Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells},
 volume = {20},
 year = {2019}
}