{"created":"2023-07-27T06:57:51.987449+00:00","id":55313,"links":{},"metadata":{"_buckets":{"deposit":"d827b92a-81a4-41b6-9d62-ba0629154351"},"_deposit":{"created_by":18,"id":"55313","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"55313"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00055313","sets":["1132:1133:1134"]},"author_link":["22514","22559","22555","22757","2771","32","89977","77295","22556","72008","22526"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"234632","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"2014","bibliographic_titles":[{"bibliographic_title":"Journal of Hormones"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"向井, 加奈恵"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中島, 由加里"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"須釜, 淳子"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"中谷, 壽男"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cutaneous wound healing is delayed by protein malnutrition (PM). On the other hand, estrogen promotes cutaneous wound healing by its anti-inflammatory and cell proliferation effects. Therefore, we hypothesized that estrogen administration in protein-malnourished ovariectomized (OVX) female mice might improve the inflammatory response and promote cutaneous wound healing as well as normal nutrition. To test this hypothesis, we used full-thickness excisional wounds in Control SHAM, PM SHAM, PM OVX and PM OVX+17β-estradiol mice. The Control diet included 200 g/kg protein and the PM diet included 30 g/kg protein. The ratio of wound area in the Control SHAM group was significantly smaller than those in the three PM groups. In addition, microscopic findings also showed that the ratio of collagen fibers, the ratio of myofibroblasts and the number of new blood vessels in the Control SHAM group were significantly greater than those in the three PM groups. However, the number of Ym1-positive cells as an anti-inflammatory M2-like macrophage marker in the PM OVX+17β-estradiol group was significantly higher than those in the other three groups. These results indicate that the appearance of anti-inflammatory M2-like macrophages was promoted by estrogen administration; however, it could not promote cutaneous wound healing upon a low-protein diet. Therefore, it may be confirmed that nutrition is more important for promoting cutaneous wound healing than estrogen administration.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00061588","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0115564","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115564"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115564","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright: © 2014 Mukai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2356-7449","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mukai, Kanae"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Komatsu, Emi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakajima, Yukari"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Urai, Tamae"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nasruddin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugama, Junko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nakatani, Toshio"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-09"}],"displaytype":"detail","filename":"ME-PR-NAKATANI-T-2014_1-8.pdf","filesize":[{"value":"384.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKATANI-T-2014_1-8.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/55313/files/ME-PR-NAKATANI-T-2014_1-8.pdf"},"version_id":"b36a57be-5093-4496-b7b7-72e43c534555"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The effect of 17s-estradiol administration on cutaneous wound healing in 24-week ovariectomized female mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The effect of 17s-estradiol administration on cutaneous wound healing in 24-week ovariectomized female mice."}]},"item_type_id":"4","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-09"},"publish_date":"2021-04-09","publish_status":"0","recid":"55313","relation_version_is_last":true,"title":["The effect of 17s-estradiol administration on cutaneous wound healing in 24-week ovariectomized female mice."],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T15:22:18.703288+00:00"}