@article{oai:kanazawa-u.repo.nii.ac.jp:00055467,
 author = {Morita, Katsuya and Hayashi, Yoshinobu and Ietsugu, Kenichi and Shimizu, Junzo and Murakami, Shinya and Oda, Makoto and Arano, Yoshihiko and Tokuraku, Masato and Nagao, Shin and Yamazaki, Ushio and Watanabe, Yoh and 森田, 克哉 and 林, 義信 and 家接, 健一 and 清水, 淳三 and 村上, 眞也 and 小田, 誠 and 荒能, 義彦 and 徳楽, 正人 and 長尾, 信 and 矢崎, 潮 and 渡辺, 洋宇},
 issue = {7},
 journal = {日本呼吸器外科学会雑誌, The journal of the Japanese association for chest surgery},
 month = {Nov},
 note = {原発性非小細胞肺癌切除65例に対し, PCNA発現率で評価した腫瘍増殖能とリンパ節転移との関連について検討を行い, 生物学的悪性度の指標としての有用性について考察した.PCNA標識率は, 手術材料を用いてflow cytometerにより複数部位で測定し, その平均値で評価した.腺癌36例中13例, 扁平上皮癌29例中5例にリンパ節転移を認め, その頻度は腫瘍径の増大にしたがって増加した.しかしPCNA標識率とリンパ節転移の頻度は相関を認めず, また腺癌では腫瘍径とも相関を認めなかった.腫瘍径が同一の場合, PCNA標識率が高値すなわちdoubling timeが短い方が発癌から発見までの期間が短かいと考えられ, 腺癌ではT1でかつPCNA標識率が高値のものでリンパ節転移を認めなかった.PCNA標識率は腫瘍の動的状態を反映すると考えられる増殖能を表しており, 癌のある時点での進行度を表すTNM分類とは独立した因子と考えられた., Proliferating cell nuclear antigen (PCNA) expression was studied in relation to the frequency of lymphnode metastasis in 65 resected non-small cell lung cancers. PCNA labeling index (LI) % was assayed objectively with flow cytometry. Lymphnode metastasis was found in 13 of 36 adenocarcinomas and in 5 of 29 squamous cell carcinomas. The frequency of lymphnode metastasis correlated positively with tumor size but not with PCNA LI%. In adenocarcinomas, there was no currelation between tumor size and PCNA LI%, but there was no lymphnode metastasis when the tumor was less than 30 mm in diameter and the PCNA LI % was high. It was concluded that PCNA LI% did not correlate with other prognostic factors but showed proliferating potential., 金沢大学医薬保健研究域医学系},
 pages = {768--772},
 title = {原発性非小細胞肺癌の PCNA 発現率で評価した腫瘍増殖能とリンパ節転移の検討},
 volume = {8},
 year = {1994}
}