@article{oai:kanazawa-u.repo.nii.ac.jp:00055585,
 author = {中沼, 伸一 and 宮下, 知治 and 高村, 博之 and 林, 泰寛 and 田島, 秀浩 and 牧野, 勇 and 尾山, 勝信 and 中川原, 寿俊 and 伏田, 幸夫 and 太田, 哲生 and Nakanuma, Shinichi and Miyashita, Tomoharu and Hayashi, Hironori and Tajima, Hidehiro and Takamura, Hiroyuki and Makino, Isamu and Oyama, Katsunobu and Nakagawara, Hisatoshi and Fushida, Sachio and Ohta, Tetsuo},
 issue = {6},
 journal = {Experimental and Clinical Transplantation},
 month = {Dec},
 note = {Objectives: Continuous thrombocytopenia after liver transplant is associated with a less favorable prognosis, but this pathogenesis remains unclear. We focused on the consumption of platelets in the allograft. We assessed platelet consumption in allografts, and evaluated the pathology of platelet aggregation in an allograft tissue and its involve-ment in clinical outcomes.

Materials and Methods: We took biopsy specimens from 20 patients. To examine the localization of platelet aggregation, CD42b was assayed immuno-histochemically, and its level of expression correlated with clinical data and outcomes.

Results: Platelet aggregation in zone 3 was 70%, compared with 30% in zone 1 and 50% in zone 2. Platelets were found mainly as extravasated platelet aggregates in local microenvironments. Patients were stratified according to the extent of extravasated platelet aggregates in zone 3 into extravasated platelet aggregate-negative and -positive groups. Graft weight/recipient body weight ratio with the extravasated platelet aggregate-positive group was significantly lower than that of the extravasated platelet aggregate-negative group. Platelet count after surgery was lower, while total bilirubin and prothrombin time/international normalized ratio were higher in the extravasated platelet aggregate-positive than they were in the extravasated platelet aggregate-negative group.

Conclusions: Extravasated platelet aggregates in the zone 3 of allograft tissue cause the consumption of platelets and continuous thrombocytopenia after transplant, and may be the clinical marker for deterioration of graft function. Platelet activation and degranulation following the release by platelets of some negative regulators may be involved partially in liver damage., 金沢大学附属病院肝胆膵・移植外科},
 pages = {556--562},
 title = {Extravasated Platelet Aggregation in Liver Zone 3 Is Associated With Thrombocytopenia and Deterioration of Graft Function After Living-Donor Liver Transplant},
 volume = {13},
 year = {2015}
}