{"created":"2023-07-27T06:58:05.980870+00:00","id":55731,"links":{},"metadata":{"_buckets":{"deposit":"c4fa0447-f000-406b-a2b6-7a368b0849bf"},"_deposit":{"created_by":18,"id":"55731","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"55731"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00055731","sets":["2812:2813:2818"]},"author_link":["97909"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2013 – 2015","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"涙腺にはステロイド合成系が発現しており、数種類のステロイドホルモンが合成されている。本研究では、涙腺における局所ステロイド合成酵素の発現解析を行い、局所ステロイドホルモンの涙腺における生理的役割を検討する。\nドライアイモデルラットの涙腺中ステロイド合成酵素の活性を測定したところ、シトクロムP45017α活性の上昇が確認できた。この活性上昇はP45017αおよびシトクロムb5発現の上昇によるものであった。ドライアイモデルでは涙腺中ジヒドロテストステロン濃度が上昇しており、この変動はP45017α活性上昇に起因すると考えられた。涙腺機能は局所ステロイドホルモンによる調節を受けていると思われる。","subitem_description_type":"Abstract"},{"subitem_description":"The lacrimal gland function was affected by steroid hormones. According to the classical theories of endocrinology, steroid hormones are synthesized in specific organs and affect the target tissues. Recent studies showed that locally-synthesized steroid hormones acted on neighboring tissues including themselves in the hippocampus, islets of Langerhans, and musculus skeleti.\nExpression of steroidogenic enzymes was elucidated by real-time RT-PCR and Immunohistochemical analysis. Activity of steroidogenic enzymes was assayed using LC-MS/MS. In dry eye model rat, the activity of cytochrome P45017α increased accompanied with increase of expressions of P45017α and cytochrome b5 compared with normal rat. LC-MS/MS analysis revealed that dihydrotestosterone (DHT) in lacrimal glands increased in dry eye model rat. Increase of DHT was thought to be caused by increase of P45017α activity. It was considered that the function of lacrimal gland was regulated by locally-produced steroid hormones.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25462733, 研究期間(年度):2013 - 2015","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「涙腺における局所ステロイド産生とその生理的役割の解明」課題番号25462733\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-25462733/25462733seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学先端科学・社会共創推進機構 / 慶應義塾大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00062006","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20383755"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20383755","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25462733/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25462733/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-25462733/25462733seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-25462733/25462733seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-06-04"}],"displaytype":"detail","filename":"ME-PR-HIGUCHI-A-kaken 2016-6p.pdf","filesize":[{"value":"300.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HIGUCHI-A-kaken 2016-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/55731/files/ME-PR-HIGUCHI-A-kaken 2016-6p.pdf"},"version_id":"5d059ef8-7910-47dd-846e-b8dc8c1079e4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"涙腺における局所ステロイド産生とその生理的役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"涙腺における局所ステロイド産生とその生理的役割の解明"},{"subitem_title":"Locall-produced steroid hormones regulate lacrimal gland function.","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-06-04"},"publish_date":"2021-06-04","publish_status":"0","recid":"55731","relation_version_is_last":true,"title":["涙腺における局所ステロイド産生とその生理的役割の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:56:21.323764+00:00"}