{"created":"2023-07-27T06:58:06.025310+00:00","id":55732,"links":{},"metadata":{"_buckets":{"deposit":"c5e8c136-b9ee-4c8d-88f2-7523c86ba8bf"},"_deposit":{"created_by":18,"id":"55732","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"55732"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00055732","sets":["2812:2813:2818"]},"author_link":["97904"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2014 – 2015","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は卵巣粘液性腫瘍に関して、特に胃腸型と内頚部型の違いに着目して研究を遂行した。内頚部型粘液性腫瘍に関しては、内膜症関連腺癌（明細胞腺癌、類内膜腺癌）で高頻度に変異が存在することが知られているARID1A遺伝子の異常の有無を検討した。その結果、内頚部型境界悪性粘液性腫瘍の一部にARID1A異常が検出された。ARID1A異常は併存する内膜症性上皮において確認された。ARID1A異常は胃腸型粘液性腫瘍においては確認されなかった。以上の結果から、内頚部型粘液性腫瘍の発生にARID1A異常が関与していること、ARID1A異常は腫瘍発生の早期の段階で起きることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We investigated ovarian mucinous tumor focusing on the difference between gastrointestinal-type and endocervical-type mucinous tumors. With regard to endocervical-type mucinous tumors, we investigated ARID1A alterations which is known to play an oncogenic role in endometriosis-associated ovarian cancer. As a result, loss of ARID1A expression, which suggests presence of mutation, was observed in a subset of endocervical-type mucinous borderline tumor. The loss of ARID1A expression was also observed in adjacent endometriotic epithelium. This finding suggest that ARID1A is involved in tumorigenesis of endocervical-type mucinous tumors. Further, ARID1A alteration occur in an early phase of its tumorigenesis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26870129, 研究期間(年度):2014 - 2015","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「卵巣粘液性腺癌の発生と進展に関する病理遺伝子学的研究」課題番号26870129\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26870129/26870129seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 秋田大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00062007","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30585500"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30585500","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26870129/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26870129/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26870129/26870129seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26870129/26870129seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-06-04"}],"displaytype":"detail","filename":"ME-PR-MAEDA-D-kaken 2016-6p.pdf","filesize":[{"value":"618.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MAEDA-D-kaken 2016-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/55732/files/ME-PR-MAEDA-D-kaken 2016-6p.pdf"},"version_id":"1a7e97ec-bbf0-4800-9d91-1c826122491c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"卵巣粘液性腺癌の発生と進展に関する病理遺伝子学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"卵巣粘液性腺癌の発生と進展に関する病理遺伝子学的研究"},{"subitem_title":"Pathological and genomic study of ovarian mucinous adenocarcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-06-04"},"publish_date":"2021-06-04","publish_status":"0","recid":"55732","relation_version_is_last":true,"title":["卵巣粘液性腺癌の発生と進展に関する病理遺伝子学的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:56:19.758692+00:00"}