{"created":"2023-07-27T06:58:06.207736+00:00","id":55736,"links":{},"metadata":{"_buckets":{"deposit":"27803f5b-5093-4b0e-8ccc-a6f23bbd56ae"},"_deposit":{"created_by":18,"id":"55736","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"55736"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00055736","sets":["2812:2813:2817"]},"author_link":["97907"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015 – 2016","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"血管内皮細胞には多様性が存在し、一部には幹細胞様の性質を持つ内皮細胞が存在することが分かっている。今回腫瘍血管内皮細胞中の内皮幹細胞をより詳細に検討し、腫瘍血管内皮細胞が通常の内皮細胞とどのように異なるか解析を行った。腫瘍血管では内皮幹細胞が非常に高い割合で存在することが明らかとなった。また移植実験から、腫瘍血管内皮細胞も階層性を持つ内皮細胞集団であることが分かった。さらに遺伝子解析で薬剤耐性に関与する蛋白の上昇を特に幹細胞分画で認めた。薬剤耐性能に関わる蛋白の阻害剤にて内皮幹細胞の増殖阻害を認め、さらには腫瘍縮小効果も認めた。今後、血管内皮幹細胞システムを標的とした治療が期待できる。","subitem_description_type":"Abstract"},{"subitem_description":"We have been studying the endothelial stem cell system in the vasculature. Here we identified this endothelial stem cell system in the tumor vasculature. In the tumor vasculature, the percentage of endothelial stem cells was significantly increased compared to normal tissue. Moreover, we showed endothelial hierarchy by transplantation model. By gene expression analysis, we found that endothelial stem cell in the tumor highly express drug resistance genes. Addition of an inhibitor which blocks the function of drug resistance protein inhibited the colony formation of endothelial stem cells. Furthermore, administration of this inhibitor to the tumor bearing mice induced regression of tumor size of these mice. Our results suggest the existence of endothelial hierarchy system in the tumor vasculature. Targeting this system may be a promising therapeutic target in the future.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K18409, 研究期間(年度):2015 - 2016","subitem_description_type":"Other"},{"subitem_description":"出典：「腫瘍血管における血管内皮幹細胞システムの破綻」研究成果報告書　課題番号15K18409\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18409/15K18409seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 大阪大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00062011","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30570676"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30570676","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K18409/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K18409/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18409/15K18409seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18409/15K18409seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-06-04"}],"displaytype":"detail","filename":"ME-PR-NAITO-H-kaken 2017-4p.pdf","filesize":[{"value":"746.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAITO-H-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/55736/files/ME-PR-NAITO-H-kaken 2017-4p.pdf"},"version_id":"8772e97d-59b9-4fda-a34f-7302ccca9db7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腫瘍血管における血管内皮幹細胞システムの破綻","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍血管における血管内皮幹細胞システムの破綻"},{"subitem_title":"Endothelial Stem Cell System in the Tumor Vasculature","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-06-04"},"publish_date":"2021-06-04","publish_status":"0","recid":"55736","relation_version_is_last":true,"title":["腫瘍血管における血管内皮幹細胞システムの破綻"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:35:41.415642+00:00"}