{"created":"2023-07-27T06:58:06.744142+00:00","id":55748,"links":{},"metadata":{"_buckets":{"deposit":"54838432-bc0c-4100-9273-d7af8f58e076"},"_deposit":{"created_by":18,"id":"55748","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"55748"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00055748","sets":["2812:2813:4085"]},"author_link":["97904"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-09-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2019-04-01 – 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maeda, Daichi"}],"nameIdentifiers":[{"nameIdentifier":"97904","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30585500","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30585500"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Genetic background of the uterine sarcomas remain largely unknown. Furthermore, there has been confusion regarding histological classification of there rare tumors. In this study, we utilized next generation sequencing to reveal mutations and fusion genes involved in the tumorigenesis of uterine sarcoma. We developed a gene panel that covers a large number of genes that are known to be altered in uterine sarcomas and applied it to actual cases. As a result, we identified uterine low-grade endometrial stromal sarcoma harboring JAZF1 fusion gene, and also a sarcoma that harbors GREB1 fusion. These findings would lead to elucidation of the genetic landscape of uterine sarcomas.","subitem_description_type":"Abstract"},{"subitem_description":"子宮肉腫の背景遺伝子異常については未だ不明な部分が多い。また、子宮肉腫の組織分類は、変遷が続いており、病理診断の現場では少なからず混乱が生じている。本研究では、子宮肉腫の遺伝子変異、融合遺伝子を検出するにあたって、次世代シーケンサー(NGS)を活用した。具体的には多数の遺伝子を網羅する独自のパネルを構築し、それらを用いて診断困難な子宮肉腫の背景遺伝子異常を探索した。その結果、JAZF1融合遺伝子を有する子宮内膜間質肉腫のみならず、GREB1融合遺伝子を有する稀な腫瘍の同定に至っている。","subitem_description_type":"Abstract"},{"subitem_description":"子宮肉腫の成り立ちを背景遺伝子異常の観点から整理し、より正確な病理診断を可能とすることで、適切な治療への誘導が可能になると考えられる。子宮肉腫に関しては様々な融合遺伝子の存在が知られるようになってきている。我々が開発した遺伝子パネルはその多くをカバーするもので、それを用いて今後、多数例の検討を行うことで、日本人の子宮肉腫の全貌を明らかにしていくことが可能だと考えいてる。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K07433, 研究期間(年度):2019-04-01 – 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「次世代シーケンス技術を活用した子宮肉腫のゲノム病理学的研究」課題番号19K07433\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07433/19K07433seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 大阪大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00062023","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30585500"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30585500","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K07433/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K07433/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07433/19K07433seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07433/19K07433seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前田, 大地"}],"nameIdentifiers":[{"nameIdentifier":"97904","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30585500","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30585500"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-27"}],"displaytype":"detail","filename":"ME-PR-MAEDA-D-kaken 2022-7p.pdf","filesize":[{"value":"88.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MAEDA-D-kaken 2022-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/55748/files/ME-PR-MAEDA-D-kaken 2022-7p.pdf"},"version_id":"fb7fc0bf-a8c9-40a8-82ae-f05f14df4d72"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"次世代シーケンス技術を活用した子宮肉腫のゲノム病理学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"次世代シーケンス技術を活用した子宮肉腫のゲノム病理学的研究"},{"subitem_title":"Pathological and genomic analyses of uterine sarcoma by next generation sequencing","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-27"},"publish_date":"2023-02-27","publish_status":"0","recid":"55748","relation_version_is_last":true,"title":["次世代シーケンス技術を活用した子宮肉腫のゲノム病理学的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:16:56.201602+00:00"}