@article{oai:kanazawa-u.repo.nii.ac.jp:00056405, author = {前田, 大地 and Suzuki, Kensuke and Nagasaka, Kazunori and Oda, Katsutoshi and abe, Hiroyuki and Maeda, Daichi and Matsumoto, Yoko and Arimoto, Takahide and Kawana, Kei and Fukayama, Masashi and Osuga, Yutaka and Fujii, Tomoyuki}, issue = {1}, journal = {BMC Cancer}, month = {Jul}, note = {Background: Lymphangioleiomyomatosis (LAM) is a rare idiopathic disorder that occurs in women of childbearing age, and consists of a diffuse proliferation of abnormal smooth muscle cells along the thoracic and abdominal lymphogenous route. Case presentation: We experienced a case of a 47-yo woman with recent history of systemic lupus erythematosus (SLE) diagnosed with endometrial cancer, initially suspected to have metastasized to pelvic and para-aortic lymph nodes based on preoperative diagnostic imaging. Subsequent pathological diagnosis revealed stage IB endometrial cancer without evidence of lymph node involvement. Instead, enlarged pelvic and para-aortic lymph nodes were found to be due to extrapulmonary LAM, from a primary lesion found inside the uterine myometrium. SLE improved after surgery. Conclusion: This is the first reported case of comorbid endometrial cancer, SLE, and aggressive LAM metastasizing to regional lymph nodes, and strengthens the clinical evidence for a common role of mTOR pathway hyperactivity and estrogen responsiveness in the pathophysiology of metastasizing lesions of the genital tract. © 2016 The Author(s)., 金沢大学医薬保健研究域医学系}, title = {A case of lymphangioleiomyomatosis associated with endometrial cancer and severe systemic lupus erythematosus}, volume = {16}, year = {2016} }