@article{oai:kanazawa-u.repo.nii.ac.jp:00056413,
 author = {前田, 大地 and Hiraike, Haruko and Wada-Hiraike, Osamu and Nakagawa, Shunsuke and Saji, Shigehira and Maeda, Daichi and Miyamoto, Yuichiro and Sone, Kenbun and Tanikawa, Michihiro and Oda, Katsutoshi and Nakagawa, Keiichi and Yano, Tetsu and Fukayama, Masashi and Taketani, Yuji},
 issue = {6},
 journal = {Experimental and Therapeutic Medicine},
 month = {Aug},
 note = {DBC1/KIAA1967 (deleted in breast cancer 1) is a putative tumor-suppressor gene cloned from breast cancer specimens and is reported to regulate p53-dependent apoptosis through its specific inhibition of SIRT1 deacetylase. Although SIRT1 plays a pivotal role in carcinogenesis by regulating cellular proliferation, survival and death, its role in breast cancer remains controversial. Therefore, we aimed to investigate the expression status and clinicopathological significance of DBC1 and SIRT1 in breast cancer tissues. We evaluated the expression of DBC1 and SIRT1 in breast core-needle biopsy specimens from 48 primary breast cancer patients between 2005 and 2008. These patients were treated with primary systemic chemotherapy and subsequent surgical resection of the lesions. Immunohistochemical expression scores of DBC1 and SIRT1 were evaluated, and the relationship between their expression levels and clinicopathological features of breast cancer was analyzed. The expression was observed exclusively in the nuclei of normal and neoplastic ductal cells. In breast biopsy specimens, positive expression of DBC1 and SIRT1 was noted in 85 and 98% of patients, respectively. Expression of DBC1 was significantly associated with the tumor nuclear grade (P=0.019). DBC1 and SIRT1 expression was inversely correlated with HER2 expression (P=0.026 and 0.003, respectively). Lower expression of DBC1 and SIRT1 indicated a tendency for a favorable pathological response to chemotherapy, although this was not statistically significant. Our results reveal that the expression of DBC1 and SIRT1 in breast tissues is associated with tumor characteristics. © 2011 Spandidos Publications Ltd., 金沢大学医薬保健研究域医学系},
 pages = {1105--1109},
 title = {Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer},
 volume = {2},
 year = {2011}
}