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Neovasculature can be induced by patching an arterial graft into a vein: A novel in vivo model of spontaneous arteriovenous fistula formation
https://doi.org/10.24517/00062703
https://doi.org/10.24517/0006270333277851-ac50-4cc7-bbff-5e886932cf71
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-MAEDA-D-3156.pdf (3.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2021-06-28 | |||||||
| タイトル | ||||||||
| タイトル | Neovasculature can be induced by patching an arterial graft into a vein: A novel in vivo model of spontaneous arteriovenous fistula formation | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00062703 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Ito, Yukinobu
× Ito, Yukinobu× Yoshida, Makoto× Maeda, Daichi× Takahashi, Masato× Nanjo, Hiroshi× Masuda, Hirotake× Gopto, Akiteru |
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| 著者別表示 |
前田, 大地
× 前田, 大地
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||
| 書誌情報 |
Scientific Reports 巻 8, 号 1, p. 3156, 発行日 2018-02-16 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 2045-2322 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1038/s41598-018-21535-2 | |||||||
| 出版者 | ||||||||
| 出版者 | Nature Research | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Arteriovenous malformations consist of tangles of arteries and veins that are often connected by a fistula. The causes and mechanisms of these clinical entities are not fully understood. We discovered that suturing an arterial patch into the common jugular vein of rabbits led to spontaneous neovascularization, the formation of an arteriovenous fistula and the development of an arteriovenous shunt. An arterial patch excised from the common carotid artery was sutured into the common jugular vein. Within a month, a dense nidus-like neovasculature formed around the patch. Angiography and pulse-oximeter analyses showed that the blood flowing into the neovasculature was arterial blood. This indicated that an arteriovenous shunt had formed. Fluorescence in situ hybridization with a Y chromosome probe in female rabbits that received an arterial patch from male rabbits showed that the vessels close to the graft bore the Y chromosome, whereas the vessels further away did not. Enzyme-linked immunosorbent assays and cDNA microarray analysis showed that multiple angiogenic factors were upregulated after patch transplantation. This is the first in vivo model of spontaneous arteriovenous fistula formation. Further research on these differences may help to improve understanding of human vascular anomaly diseases and the basic principles underlying vasculogenesis and/or angiogenesis. © 2018 The Author(s). | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © Nature Research | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.nature.com/srep/index.html | |||||||
| 関連名称 | http://www.nature.com/srep/index.html | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.nature.com/articles/s41598-018-21535-2 | |||||||
| 関連名称 | https://www.nature.com/articles/s41598-018-21535-2 | |||||||
