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Disruption of Small GTPase Rab7 exacerbates the severity of acute pancreatitis in experimental mouse models
https://doi.org/10.24517/00062704
https://doi.org/10.24517/0006270493fe8f2d-bdb7-43d7-ab2a-c0da2e523a2d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-MAEDA-D-2817.pdf (3.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2021-06-28 | |||||||
| タイトル | ||||||||
| タイトル | Disruption of Small GTPase Rab7 exacerbates the severity of acute pancreatitis in experimental mouse models | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00062704 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Takahashi, Kenichi
× Takahashi, Kenichi× Mashima, Hirosato× Miura, Kouichi× Maeda, Daichi× Goto, Akiteru× Gotio, Takashi× Sun-Wada, Ge-Hong× Wada, Yoh× Ohnishi, Hirohide |
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| 著者別表示 |
前田, 大地
× 前田, 大地
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||
| 書誌情報 |
Scientific Reports 巻 7, 号 1, p. 2817, 発行日 2017-06-06 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 2045-2322 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1038/s41598-017-02988-3 | |||||||
| 出版者 | ||||||||
| 出版者 | Nature Research | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Although aberrations of intracellular vesicle transport systems towards lysosomes including autophagy and endocytosis are involved in the onset and progression of acute pancreatitis, the molecular mechanisms underlying such aberrations remain unclear. The pathways of autophagy and endocytosis are closely related, and Rab7 plays crucial roles in both. In this study, we analyzed the function of Rab7 in acute pancreatitis using pancreas-specific Rab7 knockout (Rab7Δpan) mice. In Rab7Δpan pancreatic acinar cells, the maturation steps of both endosomes and autophagosomes were deteriorated, and the lysosomal functions were affected. In experimental models of acute pancreatitis, the histopathological severity, serum amylase concentration and intra-pancreatic trypsin activity were significantly higher in Rab7Δpan mice than in wild-type mice. Furthermore, the autophagy process was blocked in Rab7Δpan pancreas compared with wild-type mice. In addition, larger autophagic vacuoles that colocalize with early endosome antigen 1 (EEA1) but not with lysosomal-associated membrane protein (LAMP)-1 were much more frequently formed in Rab7Δpan pancreatic acinar cells. Accordingly, Rab7 deficiency exacerbates the severity of acute pancreatitis by impairing the autophagic and endocytic pathways toward lysosomes. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © Nature Research | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.nature.com/srep/index.html | |||||||
| 関連名称 | http://www.nature.com/srep/index.html | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.nature.com/articles/s41598-017-02988-3 | |||||||
| 関連名称 | https://www.nature.com/articles/s41598-017-02988-3 | |||||||
