{"created":"2023-07-27T06:58:16.022763+00:00","id":56432,"links":{},"metadata":{"_buckets":{"deposit":"69ef5c4a-6f43-425b-9b05-78aff182903e"},"_deposit":{"created_by":18,"id":"56432","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"56432"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00056432","sets":["1132:1133:1134"]},"author_link":["98778","98775","98786","98783","98780","98782","98791","98777","98779","98789","98787","98776","97904","98788","98793","98781","98790","98785","98774"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"32","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Virology Journal"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前田, 大地"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Human papillomavirus (HPV) infection is a primary cause of cervical cancer. Although epidemiologic study revealed that carcinogenic risk differs according to HPV genotypes, the expression patterns of HPV-derived transcripts and their dependence on HPV genotypes have not yet been fully elucidated. Methods: In this study, 382 patients with abnormal cervical cytology were enrolled to assess the associations between HPV-derived transcripts and cervical intraepithelial neoplasia (CIN) grades and/or HPV genotypes. Specifically, four HPV-derived transcripts, namely, oncogenes E6 and E6*, E1^E4, and viral capsid protein L1 in four major HPV genotypes-HPV 16, 18, 52, and 58-were investigated. Results: The detection rate of E6/E6*increased with CIN progression, whereas there was no significant change in the detection rate of E1^E4 or L1 among CIN grades. In addition, we found that L1 gene expression was HPV type-dependent. Almost all HPV 52-positive specimens, approximately 50% of HPV 58-positive specimens, around 33% of HPV 16-positive specimens, and only one HPV18-positive specimen expressed L1. Conclusions: We demonstrated that HPV-derived transcripts are HPV genotype-dependent. Especially, expression patterns of L1 gene expression might reflect HPV genotype-dependent patterns of carcinogenesis. © 2020 The Author(s).","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00062706","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd."}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s12985-020-01306-0","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.virologyj.com/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.virologyj.com/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01306-0"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01306-0","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © BioMed Central Ltd."}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA12048316","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1743-422X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Baba, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taguchi, Ayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawata, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Konan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Satoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Mayuyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Adachi, Katsuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Seiichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwata, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsuhashi, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Daichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Komatsu, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagamatsu, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oda, Katsutoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kukimoto, Iwao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osuga, Yutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujii, Tomoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawana, Kei"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-06-28"}],"displaytype":"detail","filename":"ME-PR-MAEDA-D-32.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MAEDA-D-32.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/56432/files/ME-PR-MAEDA-D-32.pdf"},"version_id":"c157c8d6-5eb5-4abc-820b-649b858997b7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia"}]},"item_type_id":"4","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-06-28"},"publish_date":"2021-06-28","publish_status":"0","recid":"56432","relation_version_is_last":true,"title":["Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T15:15:27.627735+00:00"}