{"created":"2023-07-27T06:58:20.051549+00:00","id":56545,"links":{},"metadata":{"_buckets":{"deposit":"dd05e8a4-9a0f-4d7a-a26a-6e5aa78e0aad"},"_deposit":{"created_by":18,"id":"56545","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"56545"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00056545","sets":["2268:2269:2270"]},"author_link":["99108","99111","99112","99109","97909","99110"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-11-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"36903","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"樋口, 明弘"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The ocular surface is strongly affected by oxidative stress, which causes many ocular diseases including dry eye. Previously, we showed that selenium compounds, e.g., selenoprotein P and Se-lactoferrin, were candidates for treatment of dry eye. This paper shows the efficacy of Se-lactoferrin for the treatment of dry eye compared with Diquas as a control drug using two dry eye models and incorporation of lactoferrin into corneal epithelial cells via lactoferrin receptors. We show the efficacy of Se-lactoferrin eye drops in the tobacco smoke exposure rat dry eye model and short-term rabbit dry eye model, although Diquas eye drops were only effective in the short-term rabbit dry eye model. These results indicate that Se-lactoferrin was useful in the oxidative stress-causing dry eye model. Se-lactoferrin was taken into corneal epithelium cells via lactoferrin receptors. We identified LRP1 as the lactoferrin receptor in the corneal epithelium involved in lactoferrin uptake. Se-lactoferrin eye drops did not irritate the ocular surface of rabbits. Se-lactoferrin was an excellent candidate for treatment of dry eye, reducing oxidative stress by a novel mechanism. © 2016 The Author(s).","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学先端科学・社会共創推進機構","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00062819","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Research"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep36903","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.nature.com/srep/index.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/srep/index.html","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/articles/srep36903"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/srep36903","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Nature Research"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Higuchi, Akihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Inoue, Hiroyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaneko, Yoshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oonishi, Erina"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsubota, Kazuo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-05"}],"displaytype":"detail","filename":"FR-PR-HIGUCHI-A-36903.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-HIGUCHI-A-36903.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/56545/files/FR-PR-HIGUCHI-A-36903.pdf"},"version_id":"1cfadd5b-461f-48d9-9691-e647359968aa"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals"}]},"item_type_id":"4","owner":"18","path":["2270"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-07-05"},"publish_date":"2021-07-05","publish_status":"0","recid":"56545","relation_version_is_last":true,"title":["Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T15:14:45.108674+00:00"}