@article{oai:kanazawa-u.repo.nii.ac.jp:00056711,
 author = {内藤, 尚道 and 高倉, 伸幸 and Kidoya, Hiroyasu and Muramatsu, Fumitaka and Shimamura, Teppei and Jia, Weizhen and Satoh, Takashi and Hayashida, Yumiko and Naito, Hisamichi and Kunisaki, Yuya and Arai, Fumio and Seki, Masahide and Suzuki, Yutaka and Osawa , Tsuyoshi and Akira , Shizuo and Takakura, Nobuyuki},
 issue = {1},
 journal = {Nature Communications},
 month = {Mar},
 note = {The balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs) maintains hematopoietic homeostasis, failure of which can lead to hematopoietic disorder. HSPC fate is controlled by signals from the bone marrow niche resulting in alteration of the stem cell transcription network. Regnase-1, a member of the CCCH zinc finger protein family possessing RNAse activity, mediates post-transcriptional regulatory activity through degradation of target mRNAs. The precise function of Regnase-1 has been explored in inflammation-related cytokine expression but its function in hematopoiesis has not been elucidated. Here, we show that Regnase-1 regulates self-renewal of HSPCs through modulating the stability of Gata2 and Tal1 mRNA. In addition, we found that dysfunction of Regnase-1 leads to the rapid onset of abnormal hematopoiesis. Thus, our data reveal that Regnase-1-mediated post-transcriptional regulation is required for HSPC maintenance and suggest that it represents a leukemia tumor suppressor. © 2019, The Author(s)., 金沢大学医薬保健研究域医学系},
 title = {Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis},
 volume = {10},
 year = {2019}
}