{"created":"2023-07-27T06:58:24.017992+00:00","id":56711,"links":{},"metadata":{"_buckets":{"deposit":"ac362de3-bfbe-48ae-b004-3bfba1b4787d"},"_deposit":{"created_by":18,"id":"56711","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"56711"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00056711","sets":["1132:1133:1134"]},"author_link":["99331","99332","15659","21935","95459","99336","47825","97907","99294","24114","99337","99335","99334","99333","30770"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"1072","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Nature Communications"}]}]},"item_4_creator_36":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内藤, 尚道"}],"nameIdentifiers":[{"nameIdentifier":"97907","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30570676","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30570676"}]},{"creatorNames":[{"creatorName":"高倉, 伸幸"}],"nameIdentifiers":[{"nameIdentifier":"95459","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80291954","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80291954"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs) maintains hematopoietic homeostasis, failure of which can lead to hematopoietic disorder. HSPC fate is controlled by signals from the bone marrow niche resulting in alteration of the stem cell transcription network. Regnase-1, a member of the CCCH zinc finger protein family possessing RNAse activity, mediates post-transcriptional regulatory activity through degradation of target mRNAs. The precise function of Regnase-1 has been explored in inflammation-related cytokine expression but its function in hematopoiesis has not been elucidated. Here, we show that Regnase-1 regulates self-renewal of HSPCs through modulating the stability of Gata2 and Tal1 mRNA. In addition, we found that dysfunction of Regnase-1 leads to the rapid onset of abnormal hematopoiesis. Thus, our data reveal that Regnase-1-mediated post-transcriptional regulation is required for HSPC maintenance and suggest that it represents a leukemia tumor suppressor. © 2019, The Author(s).","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00062985","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Research / Nature Publishing Group"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41467-019-09028-w","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.nature.com/ncomms/index.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/ncomms/index.html","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/articles/s41467-019-09028-w"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41467-019-09028-w","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"copyright © Nature Research"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kidoya, Hiroyasu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muramatsu, Fumitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimamura, Teppei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jia, Weizhen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashida, Yumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naito, Hisamichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kunisaki, Yuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arai, Fumio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Seki, Masahide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Yutaka"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Osawa , Tsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akira , Shizuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takakura, Nobuyuki"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-05"}],"displaytype":"detail","filename":"ME-PR-NAITO-H-1072.pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAITO-H-1072.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/56711/files/ME-PR-NAITO-H-1072.pdf"},"version_id":"488c8b0b-227f-4ef7-b2b7-d32e472d857e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis"}]},"item_type_id":"4","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-07-05"},"publish_date":"2021-07-05","publish_status":"0","recid":"56711","relation_version_is_last":true,"title":["Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T15:14:19.851536+00:00"}