{"created":"2023-07-27T06:58:24.198915+00:00","id":56715,"links":{},"metadata":{"_buckets":{"deposit":"1996aafe-de72-4d6a-ad55-dd1f10abc2b8"},"_deposit":{"created_by":18,"id":"56715","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"56715"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00056715","sets":["1132:1133:1134"]},"author_link":["15659","99314","99316","95459","99312","99313","97907","99315","99308","24114","99310","99309","15868","99311"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-09-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"11137","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内藤, 尚道"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"高倉, 伸幸"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Partner of sld five 1 (PSF1) is an evolutionary conserved DNA replication factor involved in DNA replication in lower species, which is strongly expressed in normal stem cell populations and progenitor cell populations. Recently, we have investigated PSF1 functions in cancer cells and found that PSF1 plays a significant role in tumour growth. These findings provide initial evidence for the potential of PSF1 as a therapeutic target. Here, we reveal that PSF1 contains an immunogenic epitope suitable for an antitumour vaccine. We analysed PSF1 peptides eluted from affinity-purified human leukocyte antigen (HLA) by mass spectrometry and identified PSF179-87 peptide (YLYDRLLRI) that has the highest prediction score using an in silico algorithm. PSF179-87 peptide induced PSF1-specific cytotoxic T lymphocyte responses such as the production of interferon-γ and cytotoxicity. Because PSF1 is expressed in cancer cell populations and highly expressed in cancer stem cell populations, these data suggest that vaccination with PSF179-87 peptide may be a novel therapeutic strategy for cancer treatment. © 2017 The Author(s).","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00062989","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Research / Nature Publishing Group"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-017-11605-2","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.nature.com/srep/index.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/srep/index.html","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/articles/s41598-017-11605-2"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41598-017-11605-2","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"copyright © Nature Research"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Mari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishioka, Yukichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ozawa, Takamasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okuyama, Hirohisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iguchi, Motofumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Takaomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagira, Morio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morita, Atsushi "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Hidekazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naito, Hisamichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kidoya, Hiroyasu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takakura, Nobuyuki"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-05"}],"displaytype":"detail","filename":"ME-PR-NAITO-H-11137.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAITO-H-11137.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/56715/files/ME-PR-NAITO-H-11137.pdf"},"version_id":"5fcf60de-6982-4cec-a311-ffc64f9416b7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency"}]},"item_type_id":"4","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-07-05"},"publish_date":"2021-07-05","publish_status":"0","recid":"56715","relation_version_is_last":true,"title":["Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T15:14:25.613121+00:00"}