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A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice
https://doi.org/10.24517/00062992
https://doi.org/10.24517/00062992bc29fb36-bc60-4b82-9fa3-22c139557997
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-NAITO-H-1327.pdf (3.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2021-07-05 | |||||||||
| タイトル | ||||||||||
| タイトル | A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00062992 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Sakimoto, Susumu
× Sakimoto, Susumu× Kidoya, Hiroyasu× Naito, Hisamichi× Kamei, Motohiro× Sakaguchi, Hirokazu× Goda, Nobuhito× Fukamizu, Akiyoshi× Nishida , Kohji× Takakura, Nobuyuki |
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| 著者別表示 |
内藤, 尚道
× 内藤, 尚道
× 高倉, 伸幸
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||||
| 書誌情報 |
Development 巻 139, 号 7, p. 1327-1335, 発行日 2012-04-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0950-1991 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1477-9129 | |||||||||
| NCID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA10667805 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1242/dev.072330 | |||||||||
| 出版者 | ||||||||||
| 出版者 | The Company of Biologists [Society | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Interactions between astrocytes and endothelial cells (ECs) are crucial for retinal vascular formation. Astrocytes induce migration and proliferation of ECs via their production of vascular endothelial growth factor (VEGF) and, conversely, ECs induce maturation of astrocytes possibly by the secretion of leukemia inhibitory factor (LIF). Together with the maturation of astrocytes, this finalizes angiogenesis. Thus far, the mechanisms triggering LIF production in ECs are unclear. Here we show that apelin, a ligand for the endothelial receptor APJ, induces maturation of astrocytes mediated by the production of LIF from ECs. APJ (Aplnr)- and Apln-deficient mice show delayed angiogenesis; however, aberrant overgrowth of endothelial networks with immature astrocyte overgrowth was induced. When ECs were stimulated with apelin, LIF expression was upregulated and intraocular injection of LIF into APJ-deficient mice suppressed EC and astrocyte overgrowth. These data suggest an involvement of apelin/APJ in the maturation process of retinal angiogenesis. © 2012. Published by The Company of Biologists Ltd. | |||||||||
| 権利 | ||||||||||
| 権利情報 | copyright © The Company of Biologists | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://dev.biologists.org/ | |||||||||
| 関連名称 | http://dev.biologists.org/ | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://journals.biologists.com/dev/article/139/7/1327/45572/A-role-for-endothelial-cells-in-promoting-the | |||||||||
| 関連名称 | https://journals.biologists.com/dev/article/139/7/1327/45572/A-role-for-endothelial-cells-in-promoting-the | |||||||||
