{"created":"2023-07-27T06:58:25.845733+00:00","id":56795,"links":{},"metadata":{"_buckets":{"deposit":"9b6bc2d0-2dda-4c03-8761-51d4e1d83f62"},"_deposit":{"created_by":18,"id":"56795","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"56795"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00056795","sets":["2812:2813:2827"]},"author_link":["91488","20737"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-05-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"2004 – 2006","bibliographic_titles":[{"bibliographic_title":"平成18(2006)年度 科学研究費補助金 基盤研究(C) 研究成果報告書概要"},{"bibliographic_title":"2006 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、癌を対象とした分子イメージング薬剤並びに分子イメージングによる治療モニタリング法の開発を目的とした。そこで、まず、新規分子イメージング薬剤としては、種々の癌に発現が確認されているシグマレセプターをターゲットとして、シグマレセプターに高い親和性を有する薬剤開発に関する基礎的研究を行った。これまでに、ベサミコールがシグマ受容体に高い親和性を持つことが報告されていることから、ベサミコールを基本骨格として新規シグマ受容体リガンドを探索した結果、ベサミコール誘導体の(+)の光学活性体で、ベサミコール誘導体のフェニルピペリジン部分のパラ位にヨウ素を導入した化合物がシグマ受容体に対して高い親和性を示した。そこで、放射性ヨウ素標識体の前駆体となりうるトリブチルスズ体であるp-トリブチルスズベサミコールの合成行い、総収率15.1%で合成した。また、p-トリブチルスズベサミコールから高収率で、[^<125>I]pIVを高収率で得ることに成功し、シグマレセプターが発現している腫瘍の診断剤としての可能性が示された。一方、分子イメージングによる治療モニタリング法としては、担癌マウスに化学療法や血管新生阻害治療を施した際の^<99m>Tc-MIBI、^<99m>Tc-HL91といったトレーサーの腫瘍への集積の変化についての研究を行った。その結果、^<99m>Tc-MIBIの集積は化学療法によって治療前に比べて減少し、^<99m>Tc-HL91の集積は増加した。それに対して、血管新生阻害治療時には治療前と治療後でトレーサーの腫瘍への集積に有意な差は観察されなかった。これら結果により、血管新生阻害治療効果をトレーサーで評価する場合、化学療法の治療効果評価とは異なった見方をすべきであることが示された。","subitem_description_type":"Abstract"},{"subitem_description":"Fvourable effects of cytotoxic chemotherapy for tumours are characterized by the reduced accumulation of radiotracers such as ^<99m>Tc sestamibi (MIBI). Antiangiogenic therapy is primarily cytostatic consequently, its influence on tracer accumulation may differ from that of cytotoxic treatments.\nAti-angiogenic therapy employing 2-methoxyestradiol was administered in mice bearing subcutaneous xenografts of LS180 colon cancer cells. The effects of chemotherapy with 5-fluorouracil were examined as a cytotoxic counterpart. Treatments were conducted for 4 days from day 8. Distribution of ^<99m>Tc-MIBI and ^<99m>Tc-HL91, a hypoxic marker, was observed on days 8 and 12. Oxygen tension (PO_2) in tumours was measured by a microelectrode. Cellular uptake of tracers was examined in vitro in normoxic and hypoxic conditions.\n^<99m>Tc-MIBI accumulation decreased with increasing tumour weight when no treatment was conducted. Tumour growth was suppressed by anti-angiogenic therapy and chemotherapy. ^<99m>Tc-MIBI accumulation in tumours decreased after chemotherapy as compared to pretherapeutic values, whereas accumulation of ^<99m>Tc-HL91 increased. In contrast, accumulation of tracers did not significantly change after anti-angiogenic therapy as compared to that observed pre-therapeutically. Tumour PO_2 decreased with increasing tumour volume when no treatment was conducted. Chemotherapy reduced PO_2 in tumours. PO_2 in tumours treated with anti-angiogenic therapy was as high as that observed before treatment. 2-Methoxyestradiol or 5-fluorouracil did not significantly affect tracer accumulation in cells under both normoxic and hypoxic conditions in vitro.\nThese findings indicate that scintigraphic assessment of therapeutic efficacy of anti-angiogenic therapy should be performed from a perspective distinct from that of cytotoxic treatment.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16591193, 研究期間(年度):2004 – 2006","subitem_description_type":"Other"},{"subitem_description":"出典：「分子イメージングによる「がん治療指針・効果予測」に関する基盤的研究」研究成果報告書　課題番号16591193\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16591193/165911932006kenkyu_seika_hokoku_gaiyo/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00063069","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://nrid.nii.ac.jp/ja/search/?kw=90019604"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://nrid.nii.ac.jp/ja/search/?kw=90019604","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16591193/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16591193/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16591193/165911932006kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16591193/165911932006kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-29"}],"displaytype":"detail","filename":"AC-PR-MORI-H-kaken 2008-2p.pdf","filesize":[{"value":"97.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"AC-PR-MORI-H-kaken 2008-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/56795/files/AC-PR-MORI-H-kaken 2008-2p.pdf"},"version_id":"91eea7e2-08a3-44c2-a771-35be4c63640e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"分子イメージングによる「がん治療指針・効果予測」に関する基盤的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"分子イメージングによる「がん治療指針・効果予測」に関する基盤的研究"},{"subitem_title":"The foundational research on \"cancer therapy guideline and effect prediction\" by the molecular imaging.","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2827"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-29"},"publish_date":"2021-10-29","publish_status":"0","recid":"56795","relation_version_is_last":true,"title":["分子イメージングによる「がん治療指針・効果予測」に関する基盤的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:32:43.553587+00:00"}