@article{oai:kanazawa-u.repo.nii.ac.jp:00057004,
 author = {Fujii, Kumiko and Sugama, Junko and Nakatani, Toshio and Sanada, Hiromi and Okuwa, Mayumi and 藤居, 久美子 and 須釜, 淳子 and 中谷, 壽男 and 真田, 弘美 and 大桑, 麻由美},
 issue = {2},
 journal = {日本褥瘡学会誌, Japanese journal of pressure ulcer},
 month = {},
 note = {本研究の目的は, 1方向のずれが褥瘡治癒過程にどのような影響を及ぼすのかを明らかにすることである. 方法は, ラット褥瘡モデルを用いて, 圧迫と1方向(尾側方向)のずれを1kgの重りを用いて負荷した群(実験群)と圧迫のみを負荷した群(対照群)との治癒過程を肉眼的・組織学的に比較した. 肉眼的所見では実験群には局所の壊死がみられ, 対照群より治癒が遅延した. 組織学的所見では実験群で7, 14日目ともに尾側の筋層の変性が顕著であった. また, 頭側の真皮にうっ血, 出血がみられた. 対照群では, 7日目, 14日目ともに表皮の欠損はなかったが, 中央部の損傷は頭側, 尾側より強かった. 以上より, 1方向のずれと圧迫を負荷した褥瘡では尾側の皮下組織から筋層にかけての変性とそのために引き起こされる頭側の真皮のうっ血によって, 圧迫のみを負荷した褥瘡と比較して, 壊死が形成され, 治癒が遅延することが示唆された., This study aimed to clarify the effects of shear stress towards the caudal side in pressure-induced ischemic wound healing in a rat model. We compared wound healing that produced pressure combined with shear using a 1kg weight (experimental group) with wound healing that produced pressure only (control group). Macroscopic findings showed that the experimental group developed local necrosis and healing was delayed by 1 week compared with the control group. Histological findings showed that necrosis had developed to the muscle layer on the tail side and that hemostasis and bleeding occurred to the dermal layer on the head side in the experimental group over 7 and 14 days. In the control group, the wound was covered by epidermis and muscular degeneration, and necrosis in the middle was more severe than on the head and tail side. These results suggested that wounds produced by pressure and shear formed necrosis and so suffered delayed healing compared with the control group. The reason for these results might be the development of necrosis to the muscle layer on the tail side and hemostasis to the dermal layer on the head side., 日本褥瘡学会の許可を得て登録_2021.9.22, 金沢大学医薬保健研究域保健学系},
 pages = {152--159},
 title = {ずれが褥瘡治癒に及ぼす影響: ラット褥瘡モデルを持田組織学的研究},
 volume = {9},
 year = {2007}
}