{"created":"2023-07-27T06:58:39.708678+00:00","id":57540,"links":{},"metadata":{"_buckets":{"deposit":"9118a20f-fd7d-4d23-b158-1ae846e599fa"},"_deposit":{"created_by":18,"id":"57540","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"57540"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00057540","sets":["2812:2813:2832"]},"author_link":["20323"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-09-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"2000 – 2001","bibliographic_titles":[{"bibliographic_title":"平成13(2001)年度 科学研究費補助金 基盤研究(C) 研究成果報告書概要"},{"bibliographic_title":"2001 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】ラット膝関節に拘縮を作製し,その後,関節可動域運動を行い、その組織学的変化を観察する。\n【対象・方法】9週齢のウィスター系雄ラット16匹.(体重260g〜285g)を用いた。それらを無作為に4匹ずつ正常群:2週間の通常飼育,拘縮群:2週間右膝関節ギプス固定,治療群:2週間右膝関節ギプス固定後2週間関節可動域運動施行,非治療群:2週間右膝関節固定後2週間通常飼育の4群に分けた。関節可動域運動は,体幹と大腿骨を固定した上で脛骨遠位を持ち,ラットが鳴き声を上げない程度の強さで体幹長軸方向に50秒間持続的伸張を加え,10秒間屈曲位で休止するサイクルを5サイクル2週間施行した。伸張力は約350gであった。それぞれ右膝関節の病理標本を通常のヘマトキシリン・エオジン染色にて作製し,光学顕微鏡にて観察した。\n【結果】固定を行った全群で2週間のギプス固定により約30度の伸展制限を認めた。その後,治療群は固定解除直後から早期に回復が見られたが,非治療群も治療群も実験終了時には約10度の可動域制限が残った。滑膜組織は,正常群に比べ拘縮群では滑膜細胞の萎縮,滑膜下層の線維増生,微小血管の拡張とうっ血を認めた。また大腿骨後部の滑膜から軟骨への移行部においては,正常群に比べて拘縮群では大腿骨後部の滑膜から軟骨への移行部において血管の増殖を伴った滑膜の増生,微小血管の拡張が見られた。治療群ではこれらの変化は正常群に近い状態へおおむね正常化し回復傾向を示しており,非治療群では治療群のような回復傾向は見られなかった。各群において滑膜への炎症細胞の浸潤は認められなかった。\n【結論】関節可動域運動は拘縮の治療において有効な手段である可能性が示唆された。今後牽引力を変えたり温熱療法など様々理学療法を施行し,どのような治療が拘縮の治療に効果的かを検討し,滑膜以外の関節構成体についてもより詳細に解明されるべきである。","subitem_description_type":"Abstract"},{"subitem_description":"Objective : To clarify the histopathological findings of the contracture mechanism and effect of range of motion exercise (ROME), we conducted experiments to observe the histopathological changes in the synovium after knee joint immobility in rats.\nMethods : Sixteen adult male Wistar rats of nine weeks old (body weight is 260g to 285g) were used to this study. Four rats of the control group were breed normally two weeks. Twelve rats had their right knee joints immobilized with a casting fixator for two weeks. Four rats of the contracture group were mercy killed immediately after they were made contracture. Four rats of the treatment group were operated ROME of immobilized knee for two weeks. Four rats of the non-treatment group were not operated ROME of immobilized knee for two weeks. ROME was consist of the five cycles of fifty seconds stretching and ten seconds rest. Rats of the treatment group were fixed the trunk and stretched the ankle in there caudad direction. The excised knee joints were fixed in formalin, decalcified and embedded in paraffin. They were stained with hematoxylin and eosin, and the synovium was examined with a light microscope.\nResults : Atrophy of synoviocytes, fibrosis of the layer underlying the synovium, dilatation, proliferation of the synovium at the cartilage-synovium migration area and congestion of the microvasculature were observed in the contracture group. Thet treatment group was almost normalized. But the non-treatment was not as normally as the treatment group.\nConclusion : Changes in the synovium of joint contracture observed in this study was considered as a secondary disorder caused by the cast fixation. This suggests that the concept of disuse atrophy would be applicable to the synovium of articular structures. And the ROME will be invaluable to the contracture joint.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:12832015, 研究期間(年度):2000 – 2001","subitem_description_type":"Other"},{"subitem_description":"出典：「ラットの拘縮膝における滑膜の形態学的変化に関する検討」研究成果報告書　課題番号12832015\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-12832015/128320152001kenkyu_seika_hokoku_gaiyo/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00063810","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70303287"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70303287","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-12832015/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-12832015/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-12832015/128320152001kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-12832015/128320152001kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-15"}],"displaytype":"detail","filename":"ME-PR-TAKEMURA-K-kaken 2003-2p.pdf","filesize":[{"value":"110.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKEMURA-K-kaken 2003-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/57540/files/ME-PR-TAKEMURA-K-kaken 2003-2p.pdf"},"version_id":"66f63cd8-4402-4a9e-8ffa-b0448681cb56"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ラットの拘縮膝における滑膜の形態学的変化に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラットの拘縮膝における滑膜の形態学的変化に関する検討"},{"subitem_title":"Research of Pathological Changes in Synovium Knee Joint Immobility in Rats","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2832"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-15"},"publish_date":"2021-10-15","publish_status":"0","recid":"57540","relation_version_is_last":true,"title":["ラットの拘縮膝における滑膜の形態学的変化に関する検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:42:51.759822+00:00"}