{"created":"2023-07-27T06:58:41.149398+00:00","id":57601,"links":{},"metadata":{"_buckets":{"deposit":"d96e9480-d8d0-48d4-9fc1-67625075c1a0"},"_deposit":{"created_by":18,"id":"57601","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"57601"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00057601","sets":["2812:2813:2832"]},"author_link":["21301","23594"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-09-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1998 – 2001","bibliographic_titles":[{"bibliographic_title":"平成13(2001)年度 科学研究費補助金 基盤研究(C) 研究概要"},{"bibliographic_title":"2001 Research Project Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"種々の小腸粘膜障害や小腸大量切除後の小腸機能の回復には,小腸粘膜の再生増殖が必要である。この再生増殖には粘膜上皮細胞内において前初期遺伝子群である核内転写因子c-fos, c-junの活性化が関与している。本研究では,種々の病態下における小腸粘膜の再生増殖機序を解明する目的でc-fos, c-jun遺伝子の発現に着目し,ラットを用いて検討した。絶食による小腸粘膜の萎縮から摂食によって起こる再生増殖の過程における加齢の影響を検討した結果,幼少ラツトでは摂食後早期にc-fos, c-junのmRNAが発現増強し増殖活性が増強するのに対し,成熟ラットではこれらの反応は弱く増殖能が低下していることを示された。小腸阻血再灌流障害モデルでは,再灌流後早期からc-fos, c-jun mRNAの発現増強がみられ,続いて増殖活性の増加がみられた。興味深いことはc-Fos, c-Jun蛋白の発現部位がアポトーシス細胞の部位と一致していたことで,c-fos, c-junの発現は再生増殖のみならずアポトーシス誘導にも関与している可能性がある。小腸大量切除後に起こる小腸粘膜の代償性増殖の過程においても,大量切除後早期からc-fos, c-jun mRNAが発現増強し,次いで増殖活性も増加していた。以上の結果から,いずれの病態下においても小腸粘膜の再生増殖にはc-fos, c-jun遺伝子の発現が重要な役割を演じていることが明らかとなった。現在,c-fos, c-jun遺伝子の発現と関連して細胞内シグナル伝達系のついて阻血再灌流モデルで解析中である。","subitem_description_type":"Abstract"},{"subitem_description":"The immediate early genes are induced rapidly and transiently in most tissues after a wide variety of injury. These genes are regulate the expression of cellular response after injury. We investigated the expression of c-fos and c-jun genes in small intestinal mucosal epithelium of rats after various injuries. In the study to determine the effect of aging on growth of the small intestinal epithelium following fasting and refeeding, the expression of c-fos and c-jun mRNA significantly increased after refeeding in young rats than in adult rats, as well as the proliferative activity. In the study to investigate the mechanism of regeneration and degeneration of small intestinal mucosa following ischemia/reperfusion, the expression of c-fos and c-jun mRNA and the proliferative activity increased markedly after reperfusion. Interestingly, apoptotic cells were observed in villi and were consistent with the expression of c-Fos and c-Jun proteins. In the study to investigate the compensatory mucosal proliferation of the residual small intestine after massive small bowel resection, the massive small bowel group showed an increase in the expression of c-fos and c-jun mRNA after the operative procedure. From these results, overexpression of c-fos and c-jun play an important role in regenaration and proliferation of small intestinal mucosal epithelium in the studies that we performed. Now, we have been researching the signal transduction system using ischemia/reperfusion model in rats.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:10671168, 研究期間(年度):1998 – 2001","subitem_description_type":"Other"},{"subitem_description":"出典：「小腸粘膜増殖機序の遺伝子学的解析」研究成果報告書　課題番号10671168\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-10671168/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部・附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00063871","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=30196513"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=30196513","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-10671168/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-10671168/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-03"}],"displaytype":"detail","filename":"HO-PR-SHIMIZU-K-kaken 2003-2p.pdf","filesize":[{"value":"104.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-SHIMIZU-K-kaken 2003-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/57601/files/HO-PR-SHIMIZU-K-kaken 2003-2p.pdf"},"version_id":"8f53e4ca-deac-4a87-b374-63f12ef69763"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"小腸粘膜増殖機序の遺伝子学的解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小腸粘膜増殖機序の遺伝子学的解析"},{"subitem_title":"Molecular Analysis of the Mechanisms of Proliferation of the Small intestine","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2832"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-03"},"publish_date":"2021-09-03","publish_status":"0","recid":"57601","relation_version_is_last":true,"title":["小腸粘膜増殖機序の遺伝子学的解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:57:16.072191+00:00"}