{"created":"2023-07-27T06:58:43.675081+00:00","id":57695,"links":{},"metadata":{"_buckets":{"deposit":"73f38a80-a95d-426d-9612-3b1dccca25f7"},"_deposit":{"created_by":18,"id":"57695","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"57695"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00057695","sets":["2812:2813:2833"]},"author_link":["1837","91601"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-03-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1999 – 2000","bibliographic_titles":[{"bibliographic_title":"平成12(2000)年度 科学研究費補助金 基盤研究(C) 研究成果報告書概要"},{"bibliographic_title":"2000 Fiscal Year Final Research Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脊椎悪性腫瘍に対する脊椎全摘術後の脊柱再建では、インストルメントの固定性、移植骨量、移植骨のリモデリングから考え、再建部分を短縮することが有利であると考えられる。脊柱短縮が脊髄に与える影響について、成犬を用いて実験を行った。第13胸椎を全摘出し長軸方向に20mmの脊柱短縮が可能な実験モデルを作成した。短縮に伴い7.2±1.7mmの脊柱短縮(切除部分の64%)までは硬膜および脊髄は上下の脊柱管に滑走し、硬膜及び脊髄は形態的変化を生じなかった。7.2mm〜12.5±1.1mmの脊柱短縮では、硬膜にひだ状の変化が生じたが、脊髄の走行は直線状であった(n=4)。12.5mm以上の短縮では、脊髄のkinkingを生じ硬膜管は脊柱管から背側に突出した。水素クリアランス法を用いた脊髄血流量は5mm、10mm、15mm、20mmの脊柱短縮において、各々短縮前の146±10%、160±21%、102±17%、93±7%であり、5mm、10mmの脊柱短縮時の脊髄血流量が有意に増加していた(n=6)。脊髄誘発電位において、脊髄がkinkingを生じた時に振幅増大現象や電位の陽性化などの脊髄障害電位が記録された。麻酔覚醒後の後肢機能では硬膜が脊髄を圧迫する直前で固定した群(n=4)では術後麻痺を生じなかった。屈曲変形後も短縮を行った群(n=4)は術後不全麻痺を生じた。脊髄のkinkingが生じる時点までの脊柱短縮は、脊髄血流量を増加させ脊髄機能の回復に有効であると考えた。","subitem_description_type":"Abstract"},{"subitem_description":"Spinal column shortening is one of the effective modality in reconstruction of total spondylectomy. We studied morphometric and physiologic changes of the spinal cord in spinal column shortening using animal models.\n[Methods] Total spondylectomy of T12 was performed after 2 above and 2 below spinal instrumentation in 16 dogs. Spinal column was gradually shortened until the lower endplate of the T11 contacted onto the L1 upper endplate (maximum of 20 mm).\n[Results] The dural sac and the spinal cord did not change their shapes until 8 mm (44%) shortening. From 8 mm to 11.5 mm (64%) shortening, the dural sac was deformed like an accordion while the spinal cord maintained its shape. In more than 11.5 mm shortening, the dural sac buckled and became like spanworm, and the spinal cord was compressed by the buckled dura in its concave side. In the spinal cord evoked potentials study, no significant changes could be seen until 11.5 mm shortening, but augmentation of amplitude was recorded at more than 11.5 mm shortening. At 20 mm (100%) shortening, positive going potentials were seen at the level of upper endplate of the L1 vertebra.\n[Conclusion] The morphometric change of the spinal cord and the dural sac in association with spinal column shortening can be characterized in three phases ; (phase 1) no deformity of the dural sac and the spinal cord, (phase 2) shrinking and buckling of the dural sac, (phase 3) spinal cord deformity and compression by the buckled dura. The phase 1 is the safety range of for the spinal cord. The phase 2 is the warning range, and the phase 3 is the critical range.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:11671425, 研究期間(年度):1999 – 2000","subitem_description_type":"Other"},{"subitem_description":"出典：「脊柱短縮に伴う、脊髄の形態的・電気生理学的変化」研究成果報告書　課題番号11671425\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（ https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-11671425/ ）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00063965","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=00092792"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=00092792","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-11671425/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-11671425/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-10"}],"displaytype":"detail","filename":"ME-PR-TOMITA-K-kaken 2002-2p.pdf","filesize":[{"value":"110.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TOMITA-K-kaken 2002-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/57695/files/ME-PR-TOMITA-K-kaken 2002-2p.pdf"},"version_id":"b1971ec1-31be-4982-97c0-a54047cb5b3d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脊柱短縮に伴う、脊髄の形態的・電気生理学的変化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脊柱短縮に伴う、脊髄の形態的・電気生理学的変化"},{"subitem_title":"An experimental study on the influence of spinal shortening on the spinal cord","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2833"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-10"},"publish_date":"2021-09-10","publish_status":"0","recid":"57695","relation_version_is_last":true,"title":["脊柱短縮に伴う、脊髄の形態的・電気生理学的変化"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:57:50.516117+00:00"}