{"created":"2023-07-27T06:58:43.855832+00:00","id":57700,"links":{},"metadata":{"_buckets":{"deposit":"e9f2ef2d-668b-4acb-8b8d-60abcc005ab1"},"_deposit":{"created_by":18,"id":"57700","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"57700"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00057700","sets":["2812:2813:2833"]},"author_link":["95389","10118"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-03-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1999 – 2000","bibliographic_titles":[{"bibliographic_title":"平成12(2000)年度 科学研究費補助金 基盤研究(C) 研究成果報告書概要"},{"bibliographic_title":"2000 Fiscal Year Final Research Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大腸癌は、遺伝子異常の積み重ねにより、腺腫から浸潤性癌まで進行してゆくことが知られている。そこで、その過程の中で、血管新生の亢進、いわゆるangiogenic swithがどこでonとなるのかについて検討した。大腸癌病変として、腺腫、粘膜内癌(非浸潤癌)、粘膜下層まで浸潤する癌、筋層まで浸潤する癌を対象に、既に大腸癌の発育進展、転移などに重要であることが判明している、Factor VIIIによるVessel count、血管新生因子としてVascular endothelial growth factor(VEGF),Platelet derived endothelial cell growth factor(PD-ECGF)、Matrix metalloproteinase(MMP)-7を免疫染色法を用いて発現を比較検討した(PD-ECGFに関しては、癌周囲の間質)。\nその結果、いずれの因子においても粘膜内癌と粘膜下層癌との間において、有意の発現の差が認められた。他では、PD-ECGFで粘膜下層癌と筋層浸潤癌との間で差が認められた以外、有意の差は認めらなかった。つまり、大腸癌の初期進展過程において、粘膜内癌から粘膜下層癌の間において血管新生とこれをコントロールする種々の血管新生因子において発現の差がみられたことから、癌が浸潤を開始する時点に一致して、血管新生の亢進、すなわちangiogenic switchが起こるることが強く示唆された。\nまた、ヒト大腸癌株のヌードマウス同所移植モデルにおいても、癌細胞が浸潤を開始した時期に一致して、angiogenic switchがonとなることを確認した。","subitem_description_type":"Abstract"},{"subitem_description":"We have already reported that vessel count, vascular endothelial growth factor (VEGF) produced by cancer cell and platelet derived endothelial cell growth factor (PD-ECGF) produced by infiltrating cells correlate with metastasis in human colon cancer. We studied whether there is anigiogenic switch in the development of colon cancer.\nWe studied vessel count, VEGF, another angiogenic factor, basic figroblast growth factor (bFGF) and matrix metalloproteinase (MMP)-7 which is well known to be important for colon cancer, expressions in cancer cells and PD-ECGF expression in infiltrating cells in 25 adenomas, 35 mucosal cancers (in situ), 29 submucosal invasive cancers (sm) and 33 muscle propria invasive cancers (mp) by immunostaining.\nThe vessel density was 12.7Å}6.7 (SD) in adenoma, 11.8Å}8.3 in in situ, 35.0Å}17.5in sm, and 35.2Å}18.8 in mp. There was significant difference between in situ and sm (p<0.001). The intensity of VEGF expression was 0.6Å}0.4, 0.9Å}0.7, 1.7Å}0.9, and 1.8Å}0.8, respectively. There was also significant difference between in situ and sm (p<0.001). There were also significant differences in the intensity of the expression of MMP-7 and PD-ECGF between in situ and sm shown as table.\nThese results suggest that angiogenic switch \"on\" may occur between in situ and sm, in other word, start of invasion, in the development of colon cancer.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:11671217, 研究期間(年度):1999 – 2000","subitem_description_type":"Other"},{"subitem_description":"出典：「大腸癌の発育進展過程におけるangiogenic switchの発現とその抑制」研究成果報告書　課題番号11671217\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-11671217/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00063970","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=10179541"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=10179541","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-11671217/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-11671217/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-10"}],"displaytype":"detail","filename":"CA-PR-TAKAHASHI-Y-kaken 2002-2p.pdf","filesize":[{"value":"87.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TAKAHASHI-Y-kaken 2002-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/57700/files/CA-PR-TAKAHASHI-Y-kaken 2002-2p.pdf"},"version_id":"ad07af80-9b46-4642-b541-5422da485fe0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸癌の発育進展過程におけるangiogenic switchの発現とその抑制","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌の発育進展過程におけるangiogenic switchの発現とその抑制"},{"subitem_title":"Angiogenic switch in the development of colon cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2833"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-10"},"publish_date":"2021-09-10","publish_status":"0","recid":"57700","relation_version_is_last":true,"title":["大腸癌の発育進展過程におけるangiogenic switchの発現とその抑制"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:57:55.849867+00:00"}