{"created":"2023-07-27T06:58:44.577920+00:00","id":57735,"links":{},"metadata":{"_buckets":{"deposit":"8bf96b1c-0f78-4f50-b7b7-231f5eb6154a"},"_deposit":{"created_by":18,"id":"57735","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"57735"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00057735","sets":["2812:2813:2832"]},"author_link":["91578","22292"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-09-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1998 – 2000","bibliographic_titles":[{"bibliographic_title":"平成13(2001)年度 科学研究費補助金 基盤研究(C) 研究概要"},{"bibliographic_title":"2001 Research Project Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"平成10年度:ddy-Conventionalマウスを用いて伺種嗅粘膜移植を行った。手技的には鼻腔内に他の動物の嗅粘膜を移植することは可能であった。しかし,成熟マウスをドナーとして用いた場合には,一定期間観察後,移植組織は残っていなかった。幼弱なマウスをドナーとして用いたところ,何らかの上皮組織は生着したが,神経系のマーカーによる免疫染色で染色されず,また,その組織がドナーの組織かレシピエントの組織かの鑑別も困難であった。\n平成11年度:移植組織の同定がより簡単なLacZを組み込んだトランスジェニックマウスをドナーとして移植を行った。しかし,移植片の生着は認められなかった。\n平成12年度:ドナーとして近交系マウスのC57BL/6を用いて移植を行った。あらかじめドナーの嗅球を除去し成熟嗅細胞を変性脱落させ,嗅上皮内には幹細胞である基底細胞と幼弱な嗅細胞,それに支持細胞のみが存在する状態にして移植した。しかし,現在のところ,移植組織の生着は認められていない。","subitem_description_type":"Abstract"},{"subitem_description":"Objective: To develop a new treatment for olfactory disturbance transplantation of olfactory epithelium attempted to mice. Study design: Olfactory mucosa pick off donor mouse was inserted into nasal cavity of recipient mouse. Varied conditioned tissues were used for donor (ex, adult or in matured, whole or sliced mucosa, extract of basal cells). Recipient mouse was allowed to survive for 7 to 28days. An immunohistochemical analysis of transplanted tissue was done using both anti protein gene product 9.5 and olfactory marker protein antibody. Results: There were no survived olfactory neuron in recipient's nasal cavity. It is suspected that inflammation or rejection for foreign body inhibited the survive of transplanted tissue.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:10671586, 研究期間(年度):1998 – 2000","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院・医学研究科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00064005","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=20229909"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=20229909","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-10671586/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-10671586/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-10"}],"displaytype":"detail","filename":"ME-PR-MIWA-T-kaken 2003-2p.pdf","filesize":[{"value":"106.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIWA-T-kaken 2003-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/57735/files/ME-PR-MIWA-T-kaken 2003-2p.pdf"},"version_id":"5a5376fd-0c78-441d-9bfe-7f950fb037d3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"動物を用いた嗅上皮移植に関する基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"動物を用いた嗅上皮移植に関する基礎的研究"},{"subitem_title":"Basic research for olfactory nerve transplantation in mice","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2832"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-10"},"publish_date":"2021-09-10","publish_status":"0","recid":"57735","relation_version_is_last":true,"title":["動物を用いた嗅上皮移植に関する基礎的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:56:59.636178+00:00"}