{"created":"2023-07-27T06:58:44.803730+00:00","id":57751,"links":{},"metadata":{"_buckets":{"deposit":"7ed39e30-0c43-4e9f-b634-9cdbb9c6ed3f"},"_deposit":{"created_by":18,"id":"57751","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"57751"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00057751","sets":["2812:2813:2834"]},"author_link":["20110"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-10-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1998 – 1999","bibliographic_titles":[{"bibliographic_title":"平成11(1999)年度 科学研究費補助金 基盤研究(C) 研究成果報告書概要"},{"bibliographic_title":"1999 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"筋組織修復中の運動療法の役割を検討し、組織変性後の早期からの運動は、食細胞の遊走、あるいは浸潤能に障害を与え、再生機能に悪影響をおよぼす可能性を否定し、筋形成にかかわる前駆細胞である筋衛星細胞の活性化と増殖を促し、筋組織の再生が亢進されることを証明した。続いて運動療法中の筋細胞の再生に対し、微小環境がどのような役割を担っているのかを検討するため、ポリビニールアルコール製のスポンジをラット腓腹筋に埋め込み、走運動を行った。スポンジは線維芽細胞増殖因子、IV型コラーゲン、ラミニン、フィブロネクチンでcoatingし、スポンジ内に進入した筋管細胞の出現を指標に検討した。その結果、筋管細胞は間葉系細胞の遊走を促進し、線維芽細胞やマクロファージなどが集まっているような場所では形成されず、これらの細胞の機能を抑制するような環境が筋再生にとって有効と思われる。コラーゲンやフィブロネクチンが存在すると、筋管細胞の遊走と増殖は盛んになり、筋芽細胞の分化に手がかりを与える物質として重要であると思われる。ラミニンは、筋芽細胞の増殖は刺激されず、強い線維芽細胞の増殖作用が認められた。筋管細胞が形成された周辺には中程度の血管の形成が認められたが、筋管細胞は必ずしも血管と接してはいなかった。\n以上のことより、運動療法は筋細胞の再生を促した。その際、コラーゲンやフィブロネクチンが存在すると、筋管細胞の発現の頻度が一層上昇し、より筋再生は亢進するものと思われる。また、運動にともなう血流の上昇は、筋再生には必ずしも必要な条件ではないと考えられる。","subitem_description_type":"Abstract"},{"subitem_description":"The therapeutic exercise from early phase after tissue degeneration does not give a disorder to the migration or infiltration capacity of a phagocyte. Inducing the activation and proliferation of a muscle satellite cell that are a precursor cell related to muscle trimming that the regeneration of the muscular tissue is accelerated was proved. What kind of role minute environment is playing to the regeneration of a myocyte in therapeutic exercise subsequently was examined. A sponge made of polyvinyl alcohol was buried to the rat gastrocnemius muscle and was crowded and carried out therapeutic exercise. A sponge examined the appearance of the myotube cell that approached into a sponge and do coating with a fibroblast growth factor, type IV collagen laminin and fibronectin. When type IV collagen and fibronectin exist it is thought that the migration and proliferatin of the myotube cell be important as the substance that gives a clue to the differentiation of a myoblast and become brisk. As for laminin the strong proliferate action of fibroblast was recognized without the proliferation of a myoblast being stimulated. From over, therapeutic exercise induced the regeneration of a myocyte. When collagen and fibronectin exist in the case, a frequency of the onset of the myotube cell elevates more and more and muscle regeneration considered accelerating more.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:10838012, 研究期間(年度):1998 – 1999","subitem_description_type":"Other"},{"subitem_description":"出典：「運動療法による筋組織修復時の筋管細胞の形成におよぼす微小環境の影響」研究成果報告書　課題番号10838012\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-10838012/108380121999kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00064021","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=00135089"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=00135089","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-10838012/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-10838012/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-10838012/108380121999kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-10838012/108380121999kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-06"}],"displaytype":"detail","filename":"ME-PR-HAIDA-N-kaken 2001-2p.pdf","filesize":[{"value":"114.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HAIDA-N-kaken 2001-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/57751/files/ME-PR-HAIDA-N-kaken 2001-2p.pdf"},"version_id":"8feb9f64-6018-47cb-8eb8-a77e15bbb618"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"運動療法による筋組織修復時の筋管細胞の形成におよぼす微小環境の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"運動療法による筋組織修復時の筋管細胞の形成におよぼす微小環境の影響"},{"subitem_title":"Effect of therapeutic exercise on muscle regeneration -Formation of myotubes and environment-","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2834"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-06"},"publish_date":"2021-09-06","publish_status":"0","recid":"57751","relation_version_is_last":true,"title":["運動療法による筋組織修復時の筋管細胞の形成におよぼす微小環境の影響"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:55:20.057421+00:00"}