@article{oai:kanazawa-u.repo.nii.ac.jp:00058615,
 author = {麦井, 直樹 and 長谷川, 稔 and 松下, 貴史 and 濱口, 儒人 and 八幡, 徹太郎 and 染矢, 富士子 and 室野, 重之 and 藤本, 学 and 竹原, 和彦 and Mugii, Naoki and Hasegawa, Minoru and Matsushita, Takashi and Hamaguchi, Yasuhito and Oohata, Sacihe and Okita, Hirokazu and Yahata, Tetsutaro and Someya, Fujiko and Inoue, Katsumi and Murono, Shigeyuki and Fujimoto, Manabu and Takehara, Kazuhiko},
 issue = {5},
 journal = {PLoS ONE},
 month = {May},
 note = {Objective: Dysphagia develops with low frequency in patients with dermatomyositis. Our objective was to determine the clinical and laboratory features that can estimate the development of dysphagia in dermatomyositis. Methods: This study included 92 Japanese patients with adult-onset dermatomyositis. The associations between dysphagia and clinical and laboratory features including disease-specific autoantibodies determined by immunoprecipitation assays were analyzed. Results: Videofluoroscopy swallow study (VFSS) was performed for all patients with clinical dysphagia (n = 13, 14.1%) but not for patients without clinical dysphagia. Typical findings of dysphagia (pharyngeal pooling, n = 11 and/or nasal regurgitation, n = 4) was detected by VFSS in all patients with clinical dysphagia. Eleven patients with dysphagia (84.6%) had anti-transcription intermediary factor 1γ (TIF-1γ) antibody. By univariate analysis, the average age and the male to female ratio, internal malignancy, and anti-TIF-1γ antibody were significantly higher and the frequency of interstitial lung diseases and manual muscle testing (MMT) scores of sternomastoid and dertoid muscles were significantly lower in patients with dysphagia than in patients without dysphagia. Among patients with anti-TIF-1γ antibody, the mean age, the ratios of male to female and internal malignancy were significantly higher and mean MMT scores of sternomastoid muscle were significantly lower in patients with dysphagia compared with patients without dysphagia. By multivariable analysis, the risk of dysphagia was strongly associated with the existence of internal malignancy and ant-TIF-1γ antibody and was also associated with reduced scores of manual muscle test of sternomastoid muscle. Dysphagia was markedly improved after the treatment against myositis in all 13 patients. Conclusion: These findings indicate that dysphagia can develop frequently in patients with internal malignancy, anti-TIF-1γ antibody, or severe muscle weakness of sternomastoid muscle. © 2016 Mugii et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited., 金沢大学医薬保健研究域保健学系},
 title = {Oropharyngeal dysphagia in dermatomyositis: Associations with clinical and laboratory features including autoantibodies},
 volume = {11},
 year = {2016}
}