@article{oai:kanazawa-u.repo.nii.ac.jp:00058959,
 author = {Mori, Hirofumi and Shiba, Kazuhiro and Tsuji, Shiro and Matsuda, Hiroshi and Hisada, Kinichi and Kojima, Kazuhiko and 森, 厚文 and 柴, 和弘 and 辻, 志郎 and 松田, 博史 and 久田, 欣一 and 小島, 一彦},
 issue = {7},
 journal = {Radioisotopes},
 month = {},
 note = {ラット脳の3H-スピロペリドールによる受容体マクロオートラジオグラフィに関して, 基礎的検討, すなわちインキュベーション時間, 洗浄時間, 飽和実験, 作動薬, 拮抗薬による抑制効果について検討するとともに, ビデオカメラとコンピュータを組合せたVideo Digitizer Systemを用いてサブトラクションイメージを作成した。その結果, 本法はドーパミン等の受容体の形態学的分布ならびに動態の解析が可能であり, 神経精神疾患の病態解明ならびに陽電子, あるいは単光子横断断層イメージの解釈に有用と期待された。, The kinetic and pharmacological characteristics of 3H-spiroperidol binding sites were studied in slide mounted sections of rat forebrain, and optical binding conditions were defined. Using the receptor macroautoradiographic techniques with tritium-sensitive LKB sheet film, the distribution of dopamine (D2) receptor was determined in slices including striatum of rat brain. The autoradiograms were analyzed using Video Digitizer System combined with video camera and minicomputer, and the subtraction images were obtained.
These studies suggest that this quantitative receptor macroautoradiography might be useful in the explanation of etiology in the field of neuro psychiatric diseases and the fundamental studies of positron emission computed tomography, since this method has several advantages over in vivo autoradiography and in vitro receptor assay., 金沢大学疾患モデル総合研究センター},
 pages = {359--363},
 title = {ラット脳における3H-スピロペリドールによる受容体マクロオートラジオグラフィ},
 volume = {34},
 year = {1985}
}