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In vivo dopamine-D2 and serotonin-5-HT2 receptor binding study of risperidone and haloperidol
https://doi.org/10.24517/00065223
https://doi.org/10.24517/000652237f338b43-64f2-453f-96c5-566df81cdf04
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-SHIBA-K-47_553.pdf (523.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2022-02-21 | |||||||
| タイトル | ||||||||
| タイトル | In vivo dopamine-D2 and serotonin-5-HT2 receptor binding study of risperidone and haloperidol | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00065223 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Sumiyoshi, T.
× Sumiyoshi, T.× Kido, H.× Sakamoto, H.× Urasaki, K.× Suzuki, K.× Yamaguchi, N.× Mori, Hirofumi× Shiba, Kazuhiro× Yokogawa, K. |
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| 著者別表示 |
柴, 和弘
× 柴, 和弘
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学疾患モデル総合研究センター | |||||||
| 書誌情報 |
Pharmacology, Biochemistry and Behavior 巻 47, 号 3, p. 553-557, 発行日 1994 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0091-3057 | |||||||
| NCID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00772020 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1016/0091-3057(94)90158-9 | |||||||
| 出版者 | ||||||||
| 出版者 | 日本アイソトープ協会 Japan Radioisotope Association | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | An in vivo receptor binding technique was applied to evaluate the affinities of risperidone and haloperidol for dopamine-D2 receptors (D2) and serotonin-5-HT2 receptors (5-HT2) in rat brain with [3H]YM-09151-2 and [3H]ketanserin as selective ligands. Radioactivities were obtained in the striatum, frontal cortex, and cerebellum of the rats treated with the ligands. Time course study of receptor occupancy at 25 to 250 min after single doses of the drugs (1 mg/kg, IP) showed higher 5-HT2 occupancy in the frontal cortex and lower D2 occupancy in the striatum by risperidone than by haloperidol. Dose-response analysis of receptor occupancy revealed risperidone demonstrated higher binding affinity for 5-HT2 than for D2, while the reverse was observed with haloperidol. It appeared that risperidone (1 mg/kg, IP), but not haloperidol (1 mg/kg, IP), demonstrated regional selectivity in D2 occupancy favouring frontal cortex more than the striatum. That risperidone displayed a higher ratio of 5-HT2 to D2 in occupancy than haloperidol is in agreement with the previous findings obtained in vitro. © 1994. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright ©日本アイソトープ協会 Japan Radioisotope Association | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.sciencedirect.com/journal/pharmacology-biochemistry-and-behavior | |||||||
| 関連名称 | https://www.sciencedirect.com/journal/pharmacology-biochemistry-and-behavior | |||||||
