{"created":"2023-07-27T06:59:23.802548+00:00","id":58962,"links":{},"metadata":{"_buckets":{"deposit":"413aba09-803d-4ba6-8641-ff8f18ab7b07"},"_deposit":{"created_by":18,"id":"58962","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"58962"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00058962","sets":["4200:1874:1875"]},"author_link":["103695","91488","103691","103683","103684","103696","85011","103690","103694","43"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"169","bibliographicPageStart":"165","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Pharmacology, Biochemistry and Behavior"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森, 厚文"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"柴, 和弘"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"An in vivo receptor binding technique was applied to evaluate the affinities of clozapine (20 mg/kg), RMI-81582 (20 mg/kg), and haloperidol (1 mg/kg) for dopamine D1, D2 and serotonin 5-HT2 receptors in rat brain with [3H]-SCH23390, [3H]-YM-09151-2, and [3H]-ketanserin as selective ligands. The time course study of receptor occupancy at 25 to 250 min after intraperitoneal administration of the drugs showed higher 5-HT2 and lower D2 receptor occupancies of clozapine and RMI-81582 than those of haloperidol both in the striatum and frontal cortex. The 5-HT2/D2 ratios of receptor occupancy for clozapine and RMI-81582 were about 6 to 8 times higher than that for haloperidol. Stable occupancies of D1 receptors were observed only with RMI-81582 and clozapine, the former demonstrating the higher occupancy. These findings are in agreement with the previous findings obtained under in vitro conditions and may account for some part of the properties of atypical antipsychotic drugs. © 1994.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学疾患モデル総合研究センター","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00065224","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本アイソトープ協会 Japan Radioisotope Association"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/0091-3057(94)90471-5","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.sciencedirect.com/journal/pharmacology-biochemistry-and-behavior"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/journal/pharmacology-biochemistry-and-behavior","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright ©日本アイソトープ協会 Japan Radioisotope Association"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00772020","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0091-3057","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sumiyoshi, T."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kido, H."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, H."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Urasaki, K."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, K."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, N."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Hirofumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiba, Kazuhiro"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-21"}],"displaytype":"detail","filename":"ME-PR-SHIBA-K-49_165.pdf","filesize":[{"value":"474.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SHIBA-K-49_165.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/58962/files/ME-PR-SHIBA-K-49_165.pdf"},"version_id":"e2cbbdf2-250d-40aa-878d-2053cd5c89fb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Time course of dopamine1,2 and serotonin2 receptor binding of antipsychotics in vivo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Time course of dopamine1,2 and serotonin2 receptor binding of antipsychotics in vivo"}]},"item_type_id":"4","owner":"18","path":["1875"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-21"},"publish_date":"2022-02-21","publish_status":"0","recid":"58962","relation_version_is_last":true,"title":["Time course of dopamine1,2 and serotonin2 receptor binding of antipsychotics in vivo"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:17:39.269361+00:00"}