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Rapid reduction of σ1-receptor binding and 18F-FDG uptake in rat gliomas after in vivo treatment with doxorubicin
https://doi.org/10.24517/00065226
https://doi.org/10.24517/0006522654e11f96-4280-4cf4-ac97-79678de00b2a
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-SHIBA-K-1320.pdf (603.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2022-02-17 | |||||||
| タイトル | ||||||||
| タイトル | Rapid reduction of σ1-receptor binding and 18F-FDG uptake in rat gliomas after in vivo treatment with doxorubicin | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00065226 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Waarde, Aren van
× Waarde, Aren van× Shiba, Kazuhiro× Jong, Johan R× Ishiwata, Kiichi× Dierckx, Rudi A× Elsinga, Philip H. |
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| 著者別表示 |
柴, 和弘
× 柴, 和弘
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学疾患モデル総合研究センター | |||||||
| 書誌情報 |
Journal of Nuclear Medicine 巻 48, 号 8, p. 1320-1326, 発行日 2007 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0161-5505 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 2159-662X | |||||||
| NCID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00703684 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.2967/jnumed.107.042085 | |||||||
| 出版者 | ||||||||
| 出版者 | Society of Nuclear Medicine | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | σ-Receptors are strongly overexpressed in most rodent and human tumors and are proliferation markers. To evaluate the potential of a radiolabeled σ1-Higand for therapy monitoring, we compared early changes of 11C-1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine (11C-SA4503) binding and 18F-FDG uptake in gliomas after in vivo chemotherapy. Methods: C6 cells (2.5 × 10 6) were subcutaneously injected into the right shoulder of male Wistar rats. After 7 d, the tumor volume was 0.60 ± 0.08 cm3. Animals then received either saline or doxorubicin (8 mg/kg, intraperitoneally). One control and 1 treated rat were imaged simultaneously, 24 or 48 h after treatment, under pentobarbital anesthesia. Rodents (n = 20) were scanned first with 11C-SA4503 (25 MBq, intravenously) followed more than 100 min afterward by 18F-FDG (20 MBq, intravenously), using a dedicated small-animal PET camera (60-min protocol, tumors in the field of view). Tumor homogenates were prepared and subjected to σ-receptor assays. The biodistribution of 18F-FDG was assessed. Results: Tumors appeared 4-5 d after inoculation and grew exponentially. No significant reduction of tumor growth was visible within 48 h after doxorubicin treatment. Both PET tracers visualized the tumors and showed reduced uptake after chemotherapy ( 11C-SA4503: 26.5% ± 6.5% at 24 h, 26.5% ± 7.5% at 48 h; 18F-FDG: 22.6% ± 3.2% at 24 h, 27.4% ± 3.2% at 48 h; ex vivo 18F-FDG: 22.4% ± 5.4% at 24 h, 31.7% ± 12.7% at 48 h). σ1-Receptor density in treated tumors was also reduced (from 172 ± 35 to 125 ± 28 fmol/mg of protein). Conclusion: Both 11C-SA4503 binding and 18F-FDG uptake declined in gliomas after chemotherapy. Decreased binding of 11C-SA4503 corresponded to a loss of σ1-receptors from the tumors. Changes in tracer uptake preceded the morphologic changes by at least 48 h. Copyright © 2007 by the Society of Nuclear Medicine, Inc. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © Society of Nuclear Medicine | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://jnm.snmjournals.org/ | |||||||
| 関連名称 | http://jnm.snmjournals.org/ | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://jnm.snmjournals.org/content/48/8/1320 | |||||||
| 関連名称 | https://jnm.snmjournals.org/content/48/8/1320 | |||||||
