@article{oai:kanazawa-u.repo.nii.ac.jp:00058968,
 author = {若林, 大志 and 瀧, 淳一 and 廣正, 智 and 稲木, 杏吏 and 小阪, 孝史 and 柴, 和弘 and 小川, 数馬 and 絹谷, 清剛 and Wakabayashi, Hiroshi and Taki, Junichi and Mori, Hirofumi and HIROMASA, Tomo and Akatani, Norihito and Inaki, Anri and Kozaka, Takashi and Shiba, Kazuhiro and Ogawa, Kazuma and Kinuya, Seigo},
 issue = {11},
 journal = {Circulation Journal},
 month = {},
 note = {Background: This study chronologically evaluated the expression of the intensity and distribution of the sigma-1 receptor (σ1R) demonstrated by radiolabeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) in a rat model of myocardial ischemia and reperfusion. Methods and Results: The left coronary artery was occluded for 30 min, followed by reperfusion. Dual-tracer autoradiography with 125I-OI5V and 99 mTc-MIBI was performed to assess the spatiotemporal changes in 125I-OI5V uptake (n=5-6). Significant and peaked 125I-OI5V uptake in the ischemic area was observed at 3 days after reperfusion, and the 125I-OI5V uptake ratio of ischemic area to normally perfused left ventricular area decreased gradually from 3 to 28 days (mean value ± SD; 0.90±0.12 at 1 day, 1.89±0.19 at 3 days, 1.52±0.17 at 7 days, 1.34±0.13 at 14 days, and 1.16±0.14 at 28 days, respectively). Triple-tracer autoradiography with 125I-OI5V, 99 mTc-MIBI, and 201TlCl was performed to evaluate 125I-OI5V uptake in the ischemic area in relation to the residual perfusion at 7 days (n=4). The 125I-OI5V uptake ratio of the non-salvaged area was higher compared to that of the salvaged area in the ischemic area. 123I-OI5V and 99 mTc-MIBI SPECT/CT was performed 3 days after reperfusion (n=3), and the in vivo images showed clear uptake of 123I-OI5V in the perfusion defect area. Conclusions: The present study confirmed the spatiotemporal expression pattern of σ1R expression. Non-invasive σ1R imaging with 123I or 125I-OI5V was feasible to monitor the expression of σ1R after myocardial ischemia and reperfusion. © 2021 Japanese Circulation Society. All rights reserved., 金沢大学疾患モデル総合研究センター},
 pages = {2102--2108},
 title = {Visualization of dynamic expression of myocardial Sigma-1 receptor after myocardial Ischemia and reperfusion using radioiodine-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) imaging},
 volume = {85},
 year = {2021}
}