{"created":"2023-07-27T06:59:24.030589+00:00","id":58968,"links":{},"metadata":{"_buckets":{"deposit":"ed463d1c-cb29-437c-bd7f-42f22acf0e1d"},"_deposit":{"created_by":18,"id":"58968","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"58968"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00058968","sets":["4200:1874:1875"]},"author_link":["43","85162","80506","20737","78846","22513","1880","87","85011","78763","80505","88910","97979","103738","22187","115","102246","88911"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"2108","bibliographicPageStart":"2102","bibliographicVolumeNumber":"85","bibliographic_titles":[{"bibliographic_title":"Circulation Journal"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"若林, 大志"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"瀧, 淳一"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"廣正, 智"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"稲木, 杏吏"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小阪, 孝史"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"柴, 和弘"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"小川, 数馬"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"絹谷, 清剛"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: This study chronologically evaluated the expression of the intensity and distribution of the sigma-1 receptor (σ1R) demonstrated by radiolabeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) in a rat model of myocardial ischemia and reperfusion. Methods and Results: The left coronary artery was occluded for 30 min, followed by reperfusion. Dual-tracer autoradiography with 125I-OI5V and 99 mTc-MIBI was performed to assess the spatiotemporal changes in 125I-OI5V uptake (n=5-6). Significant and peaked 125I-OI5V uptake in the ischemic area was observed at 3 days after reperfusion, and the 125I-OI5V uptake ratio of ischemic area to normally perfused left ventricular area decreased gradually from 3 to 28 days (mean value ± SD; 0.90±0.12 at 1 day, 1.89±0.19 at 3 days, 1.52±0.17 at 7 days, 1.34±0.13 at 14 days, and 1.16±0.14 at 28 days, respectively). Triple-tracer autoradiography with 125I-OI5V, 99 mTc-MIBI, and 201TlCl was performed to evaluate 125I-OI5V uptake in the ischemic area in relation to the residual perfusion at 7 days (n=4). The 125I-OI5V uptake ratio of the non-salvaged area was higher compared to that of the salvaged area in the ischemic area. 123I-OI5V and 99 mTc-MIBI SPECT/CT was performed 3 days after reperfusion (n=3), and the in vivo images showed clear uptake of 123I-OI5V in the perfusion defect area. Conclusions: The present study confirmed the spatiotemporal expression pattern of σ1R expression. Non-invasive σ1R imaging with 123I or 125I-OI5V was feasible to monitor the expression of σ1R after myocardial ischemia and reperfusion. © 2021 Japanese Circulation Society. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学疾患モデル総合研究センター","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00065230","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Circulation Society"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1253/circj.CJ-21-0320","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.plosone.org/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.plosone.org/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/browse/circj/-char/ja/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/circj/-char/ja/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Japanese Circulation Society 日本循環器学会"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11591968","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-9843","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wakabayashi, Hiroshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Taki, Junichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Mori, Hirofumi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"HIROMASA, Tomo"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Akatani, Norihito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inaki, Anri"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kozaka, Takashi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Shiba, Kazuhiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ogawa, Kazuma"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kinuya, Seigo"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-11"}],"displaytype":"detail","filename":"ME-PR-SHIBA-K-85_2102.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SHIBA-K-85_2102.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/58968/files/ME-PR-SHIBA-K-85_2102.pdf"},"version_id":"1e339cb8-b1eb-488e-baac-8a80ae6b37e7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Visualization of dynamic expression of myocardial Sigma-1 receptor after myocardial Ischemia and reperfusion using radioiodine-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Visualization of dynamic expression of myocardial Sigma-1 receptor after myocardial Ischemia and reperfusion using radioiodine-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) imaging"}]},"item_type_id":"4","owner":"18","path":["1875"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-11"},"publish_date":"2022-03-11","publish_status":"0","recid":"58968","relation_version_is_last":true,"title":["Visualization of dynamic expression of myocardial Sigma-1 receptor after myocardial Ischemia and reperfusion using radioiodine-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) imaging"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:18:05.916985+00:00"}