@article{oai:kanazawa-u.repo.nii.ac.jp:00058969,
 author = {瀧, 淳一 and 稲木, 杏吏 and 若林, 大志 and 小川, 数馬 and 柴, 和弘 and 絹谷, 清剛 and Taki, Junichi and Inaki, Anri and Wakabayashi, Hiroshi and Matsunari, Ichiro and Imanaka-Yoshida, Kyoko and Ogawa, Kazuma and Hiroe, Michiaki and Shiba, Kazuhiro and Kinuya, Seigo},
 issue = {12},
 journal = {Circulation Journal},
 month = {Nov},
 note = {Background: Methionine uptake after myocardial infarction has been proven to reflect myocardial inflammation. The effect of postconditioning on the post-infarction inflammatory process, however, remains to be elucidated. Methods and Results: In control (n=22) and postconditioning rats (n=23), the left coronary artery was occluded for 30min, followed by reperfusion for 1, 3, 7, and 14 days. Postconditioning was performed immediately following the reperfusion. 14C-methinine (0.74MBq) and 201Tl (14.8MBq) were injected 20 and 10min prior to sacrifice, respectively. One minute before sacrifice, 150–180MBq of 99mTc-MIBI was injected immediately following the re-occlusion of the left coronary artery to verify the area at risk, and left ventricular triple-tracer autoradiography was performed. To examine the ventricular remodeling, echocardiography was performed 2 months after reperfusion in both groups (n=6 each). In the control rats, the methionine uptake ratios on days 1, 3, 7, and 14 were 0.74±0.12, 1.85±0.16, 1.48±0.10, 1.25±0.04, respectively. With postconditioning, methionine uptake was similar on day 3 (1.90±0.21), but was lower on day 7 (1.23±0.22, P<0.05) and day 14 (1.08±0.09, P<0.005). Echocardiography revealed that postconditioning reduced the ventricular end-diastolic (0.97±0.16 to 0.78±0.12cm, P<0.05) and systolic (0.85±0.21 to 0.55±0.23cm, P<0.05) dimensions and improved ventricular percentage fractional shortening (12±6.2 to 29±12 %, P=0.01). Conclusions: 14C-methinine imaging revealed that postconditioning accelerated resolution of inflammation and attenuated ventricular remodeling. © 2019 Japanese Circulation Society. All rights reserved., 金沢大学疾患モデル総合研究センター},
 pages = {2520--2526},
 title = {Postconditioning accelerates myocardial inflammatory resolution demonstrated by 14C-methionine imaging and attenuates ventricular remodeling after ischemia and reperfusion},
 volume = {83},
 year = {2019}
}