@article{oai:kanazawa-u.repo.nii.ac.jp:00058975,
 author = {吉原, 亨 and 小泉, 恵太 and 横山, 茂 and 北尾, 康子 and 堀, 修 and 浅野, 雅秀 and 北村, 暘二 and 小阪, 孝史 and 柴, 和弘 and Lopatina, Olga and Yoshihara, Toru and Nishimura, Tomoko and Zhong, Jing and Akther, Shirin and Fakhrul, Azam A.K.M. and Liang, Mingkun and Higashida, Chiharu and Sumi, Kohei and Furuhara, Kazumi and Inahata, Yuki and Huang, Jina-Jung and Koizumi, Keita and Yokoyama, Shigeru and Tsuji, Takahiro and Petugina, Yulia and Sumarokov, Andrei and Salmina, Alla B. and Hashida, Koji and Kitao, Yasuko and Hori, Osamu and Asano, Masahide and Kitamura, Yoji and Kozaka, Takashi and Shiba, Kazuhiro and Zhong, Fangfang and Xie, Min-Jue and Sato, Makoto and Ishihara, Katsuhiro and Higashida, Haruhiro},
 issue = {APR},
 journal = {Frontiers in Behavioral Neuroscience},
 month = {Apr},
 note = {CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositolanchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is known about the function of CD157 in the nervous system and contribution to PD progression. Here, we show that no apparent motor dysfunction was observed in young knockout (CD157-/-) male mice under less aging-related effects on behaviors. CD157-/- mice exhibited anxiety-related and depression-like behaviors compared with wild-type mice. These behaviors were rescued through treatment with anti-psychiatric drugs and oxytocin. CD157 was weakly expressed in the amygdala and c-Fos immunoreactivity in the amygdala was less evident in CD157-/- mice than in wild-type mice. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in PD. © 2014 Lopatina, Yoshihara, Nishimura, Zhong, Akther, Fakhrul, Liang, Higashida, Sumi, Furuhara, Inahata, Huang, Koizumi, Yokoyama, Tsuji, Petugina, Sumarokov, Salmina, Hashida, Kitao, Hori, Asano, Kitamura, Kozaka, Shiba, Zhong, Xie, Sato, Ishihara and Higashida., CC-BY 4.0, 金沢大学疾患モデル総合研究センター},
 title = {Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease},
 volume = {8},
 year = {2014}
}