{"created":"2023-07-27T06:59:24.530523+00:00","id":58980,"links":{},"metadata":{"_buckets":{"deposit":"827f4abb-98f4-40c0-b020-05bc715acdda"},"_deposit":{"created_by":18,"id":"58980","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"58980"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00058980","sets":["4200:1874:1875"]},"author_link":["43","91111","103842","86825","16659","86826","85011","78918","94574","103846","311","520","23329","2857","103845","21488"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"13260","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"菊地, 晶裕"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"柴, 和弘"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"松郷, 誠一"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"石井, 清朗"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"御簾, 博文"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"篁, 俊成"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Leukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine that causes skeletal muscle insulin resistance. The circulating levels of LECT2 are a possible biomarker that can predict weight cycling because they reflect liver fat and precede the onset of weight loss or gain. Herein, to clarify the dynamics of this rapid change in serum LECT2 levels, we investigated the in vivo kinetics of LECT2, including its plasma half-life and tissue distribution, by injecting 125I-labelled LECT2 into ICR mice and radioactivity tracing. The injected LECT2 was eliminated from the bloodstream within 10 min (approximate half-life, 5 min). In the kidneys, the radioactivity accumulated within 10 min after injection and declined thereafter. Conversely, the radioactivity in urine increased after 30 min of injection, indicating that LECT2 is mainly excreted by the kidneys into the urine. Finally, LECT2 accumulated in the skeletal muscle and liver until 30 min and 2 min after injection, respectively. LECT2 accumulation was not observed in the adipose tissue. These findings are in agreement with LECT2 action on the skeletal muscle. The present study indicates that LECT2 is a rapid-turnover protein, which renders the circulating level of LECT2 a useful rapid-response biomarker to predict body weight alterations. © 2020, The Author(s).","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"CC-BY 4.0","subitem_description_type":"Other"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学疾患モデル総合研究センター","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00065242","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Research"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-020-70192-x","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.nature.com/srep/index.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/srep/index.html","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © The Author(s) 2020. Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/."}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kikuchi, Akihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Takayama, Hiroaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tsugane, Hirohiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiba, Kazuhiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Chikamoto, Keita"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Tatsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsugo, Seiichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ishii, Kiyoaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Misu, Hirofumi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Takamura, Toshinari"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-28"}],"displaytype":"detail","filename":"ME-PR-SHIBA-K-10.13260.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SHIBA-K-10.13260.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/58980/files/ME-PR-SHIBA-K-10.13260.pdf"},"version_id":"a5a07d04-159b-42da-8d6b-50fd4554427e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice"}]},"item_type_id":"4","owner":"18","path":["1875"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-28"},"publish_date":"2022-01-28","publish_status":"0","recid":"58980","relation_version_is_last":true,"title":["Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:17:26.302817+00:00"}