@article{oai:kanazawa-u.repo.nii.ac.jp:00058985,
 author = {若林, 大志 and 瀧, 淳一 and 稲木, 杏吏 and 柴, 和弘 and 絹谷, 清剛 and Wakabayashi, Hiroshi and Taki, Junichi and Inaki, Anri and Shiba, Kazuhiro and Matsunari, Ichir and Kinuya, Seigo},
 issue = {1},
 journal = {EJNMMI Research},
 month = {Dec},
 note = {Background
To investigate whether an apoptotic process demonstrated by 99mTc-annexin-V (99mTc-AV) uptake correlates with left ventricular remodeling (LVR) after myocardial infarction, we assessed 99mTc-AV uptake in rat model of myocardial ischemia and reperfusion.

Methods
The left coronary artery (LCA) of 15 rats was occluded for 20 to 30 min, followed by reperfusion. After 2 weeks, 99mTc-AV was injected, and then 1 h later, 201Tl was injected after reocclusion of the LCA. Dual-tracer autoradiography was performed to assess 99mTc-AV uptake and the area at risk (AAR) by 201Tl defect. 99mTc-AV uptake ratio was calculated by dividing the count density of the AAR by that of the normally perfused area. In short-axis LV slices, LV cavity dilation index (DI) was calculated by dividing the area of LV cavity by that of the whole LV area. LV wall-thinning ratio (WTR) was calculated by dividing the LV wall thickness in the AAR by that of the normally perfused area.

Results
Significant 99mTc-AV uptake in the AAR was observed in 10 rats. DI was significantly higher in rats with positive 99mTc-AV uptake than in rats without uptake. WTR was smaller in rats with positive 99mTc-AV uptake than in rats without uptake.

Conclusions
The data suggest 99mTc-AV uptake in injured myocardium might correlate with LVR at 2 weeks after myocardial ischemia and reperfusion., 金沢大学疾患モデル総合研究センター},
 title = {Correlation between apoptosis and left ventricular remodeling in subacute phase of myocardial ischemia and reperfusion},
 volume = {5},
 year = {2015}
}