{"created":"2023-07-27T06:59:40.149678+00:00","id":59327,"links":{},"metadata":{"_buckets":{"deposit":"5e825cca-c419-4cb4-aaa4-ebefee69a627"},"_deposit":{"created_by":18,"id":"59327","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"59327"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00059327","sets":["2812:2813:4085"]},"author_link":["97922"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3p.","bibliographicVolumeNumber":"2021-04-01 – 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 奨励研究 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"クエン酸ナトリウムを含有する薬剤とランソプラゾール（LPZ） OD錠を同時懸濁することにより、LPZが早期に溶出することが分かった。また、クエン酸ナトリウム含有薬剤もしくはとろみ剤とLPZ OD錠の同時懸濁液を、塩酸で攪拌後に中性緩衝液で攪拌した結果、LPZの残存率が低下することが分かった。\n以上よりクエン酸ナトリウムは腸溶性コーティングを早期に破壊し、耐酸性能を低下させる可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"クエン酸ナトリウムは医薬品および医薬品添加物だけでなく、とろみ剤や服薬支援ゼリーの食品添加物としても使用されている。今回、クエン酸ナトリウムがランソプラゾール（LPZ） OD錠の腸溶性コーティングを早期に破壊し、耐酸性能を低下させると示唆されたことにより、この条件下でLPZ OD錠を投与すると、LPZは胃酸で分解され薬効が減弱する可能性が考えられた。\n今後の超高齢社会において多用される経管投与やとろみ剤等の服薬支援時における新たに注意すべき配合変化として提示できたと考えられる。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21H04188, 研究期間:2021-04-01 – 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「クエン酸ナトリウムを含む薬剤および服薬支援製剤の腸溶性コーティングに与える影響」課題番号21H04188（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21H04188/21H04188seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00065589","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=21H04188"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=21H04188","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21H04188/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21H04188/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21H04188/21H04188seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21H04188/21H04188seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-18"}],"displaytype":"detail","filename":"HO-PR-NAKAGAWA-Y-kaken 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