{"created":"2023-07-27T07:00:00.587360+00:00","id":59786,"links":{},"metadata":{"_buckets":{"deposit":"eda06781-c10e-4b68-a091-c6e65d262cd5"},"_deposit":{"created_by":18,"id":"59786","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"59786"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00059786","sets":["1777:1778:1779"]},"author_link":["85783","141","86418","302","79940","183","88142","27","86390","85781","48011","86421","2451","47514"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-10-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"16678","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"酒井, 克也 "}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"西内, 巧"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"矢野, 聖二"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"寺島, 農"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"鈴木, 健之"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"松本, 邦夫"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aggressive invasiveness of malignant mesothelioma limits cancer therapy, however, the molecular mechanisms underlying the invasiveness remain largely unknown. Here we found that the matrix metalloproteinase-2 (MMP-2) was required for the invasion of mesothelioma cells in the collagen matrix and the gene expression of MMP-2 was correlated with the invasive phenotype. The MMP-2 gene expression was regulated by DNA and histone methylation around the transcription start site, implicating the involvement of the polycomb repressive complex (PRC). Knockdown of PRC component chromobox 6 (CBX6) promoted MMP-2 expression and invasion of mesothelioma cells. Transcriptome analysis suggested that CBX6 regulates sets of genes involved in cancer cell migration and metastasis. In invasive but not non-invasive cells, CBX6 was constantly unstable owing to ubiquitination and protein degradation. In human tissues, CBX6 localized in the nuclei of normal mesothelium and benign mesothelioma, but the nuclear staining of CBX6 was lost in malignant mesothelioma. These results suggest involvement of proteasomal degradation of CBX6 in mesothelioma progression.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.","subitem_description_type":"Other"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00066041","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Research"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-020-72448-y","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/articles/s41598-020-72448-y"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41598-020-72448-y","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/srep/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/srep/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © The Author(s) 2020"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakai, Katsuya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nishiuchi, Takumi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tange, Shoichiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Suzuki, Yoshinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yano, Seiji"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Terashima, Minoru"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Suzuki, Takeshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Matsumoto, Kunio"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-12"}],"displaytype":"detail","filename":"CA-PR-SAKAI-K-16678.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SAKAI-K-16678.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/59786/files/CA-PR-SAKAI-K-16678.pdf"},"version_id":"176dd589-27c0-4259-9609-d8b0241d6bde"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion."}]},"item_type_id":"4","owner":"18","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-12"},"publish_date":"2022-05-12","publish_status":"0","recid":"59786","relation_version_is_last":true,"title":["Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion."],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:08:12.731587+00:00"}