{"created":"2023-07-27T07:00:00.633303+00:00","id":59787,"links":{},"metadata":{"_buckets":{"deposit":"cc7ee617-99dc-4bf8-a899-26d2044b1cad"},"_deposit":{"created_by":18,"id":"59787","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"59787"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00059787","sets":["1777:1778:1779"]},"author_link":["105405","105406","105402","86421","105409","2837","22744","88144","105412","86390","105378","2451","141","47965","88142","105400","105407","27","88146","105408","105403"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"606","bibliographicPageStart":"598","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Nature Chemical Biology"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"酒井, 克也 "}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"佐藤, 拓輝"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"矢野, 聖二"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"柴田, 幹大"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"松本, 邦夫"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Activation of hepatocyte growth factor (HGF) by proteolytic processing is triggered in cancer microenvironments, and subsequent signaling through the MET receptor is involved in cancer progression. However, the structure of HGF remains elusive, and few small/medium-sized molecules can modulate HGF. Here, we identified HiP-8, a macrocyclic peptide consisting of 12 amino acids, which selectively recognizes active HGF. Biochemical analysis and real-time single-molecule imaging by high-speed atomic force microscopy demonstrated that HiP-8 restricted the dynamic domains of HGF into static closed conformations, resulting in allosteric inhibition. Positron emission tomography using HiP-8 as a radiotracer enabled noninvasive visualization and simultaneous inhibition of HGF–MET activation status in tumors in a mouse model. Our results illustrate the conformational change in proteolytic activation of HGF and its detection and inhibition by a macrocyclic peptide, which may be useful for diagnosis and treatment of cancers.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Embargo Period 6 months","subitem_description_type":"Other"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00066042","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Research / Springer Nature"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41589-019-0285-7","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/articles/s41589-019-0285-7"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41589-019-0285-7","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/nchembio/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/nchembio/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © The Author(s), under exclusive licence to Springer Nature America, Inc. 2019"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11994319","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1552-4450","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1552-4469","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakai, Katsuya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Passioura, Toby"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Hiroki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ito, Kenichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furuhashi, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umitsu, Masataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takagi, Junichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Yukinari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mukai, Hidefumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Warashina, Shota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zouda, Maki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Yasuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yano, Seiji"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Shibata, Mikihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Suga, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, 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