{"created":"2023-07-27T07:00:02.363085+00:00","id":59829,"links":{},"metadata":{"_buckets":{"deposit":"bc5f055d-09d9-4bfd-bd37-165511d7451c"},"_deposit":{"created_by":18,"id":"59829","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"59829"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00059829","sets":["2812:2813:2835"]},"author_link":["20129","20664"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-12-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3p.","bibliographicVolumeNumber":"1996 – 1998","bibliographic_titles":[{"bibliographic_title":"平成10(1998)年度 科学研究費補助金 基盤研究(A) 研究成果報告書概要"},{"bibliographic_title":"1998 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1) 非小細胞肺癌でのp53蛋白陽性例の予後は陰性例に比し不良であり、特に腺癌においてこの傾向が著明であった。増殖細胞核因子(Proliferating cell nuclear antigen,PCNA標識率)の検討から、p53蛋白陽性肺癌症例の腫瘍増殖能が陰性例に比し高いことも確認した。bcl-2蛋白発現陽性率は扁平上皮癌で有意に高く、扁平上皮癌において蛋白陽性群の予後が陰性群に比し良好であった。\n2) 非小細胞肺癌では、u-PAとその関連因子の発現は担癌正常肺に比し癌組織で亢進していることが確認され、u-PAの阻害因子であるPAl-2の発現とリンパ節転移との間に負の相関関係が見られた。PAl-2非発現例は発現例に比し予後不良であり、MT-MMPが高発現例の予後が不良であった。\n3) 非小細胞肺癌では接着分子standard form CD44s(CD44s)あるいはvariant form CD44v6(CD44v6)陰性例の予後が陽性例に比し不良であった。CD44sとCD44v6がともに陰性となった群は予後不良であった。CD44の発現の減弱が肺癌の進展と関わる可能性が示唆された。\n4) 原発生肺癌における血管新生因子VEGFの遺伝子発現はSolble formの発現が高頻度に認められ、担癌正常肺に比し癌組織での発現亢進が確認された。VEGF陽性例の予後は陰性例に比し予後不良であった。VEGF遺伝子発現とリンパ節転移との相関性が確認され、ヌードマウスを用いた転移モデルにおいて、血管新生阻害剤がリンパ節転移を抑制した。\n5) 肺癌組罐におけるThrombospondin-1(TSP-1)陽性群の予後は陰性群に比し不良であった。肺癌組織において、TSP-1発現例のPCNA標識率ならびに腫瘍内血管密度はともに、非発現例に比し有意に高く、肺癌の進展に本因子は促進的に作用する可能性が示唆された。1期治癒切除例による多変量解析にて、TSP-1はVEGF発現とともに独立した予後不良因子であった。\n6) サイトケラチン陽牲の癌細胞が肺癌症例の骨髄、さらには従来の組織学的診断において転移陰牲とされたリンパ節においても少なからず存在することが確認され、予後不良因子としての可能性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"1.) As a result of immunohistochemical study, the bcl-2 protein expression in epidermoid carcinoma was higher than that in adenocarcinoma. In epidermoid carcinoma, a bcl-2 protein expressing group showed a better survival rate than a non-expressing group. A p53 protein positive group showed a poorer survival rate than a negative group. The bcl-2 expression in epidermoid carcinoma patients is a potentially valuable prognostic factor. And p53 protein might be a valuable prognostic indicator in non-small cell lung cancer, particularly in adenocarcinoma.\n2) The expression of u-PA, u-PAR, and PAT-1 was detected in approximately 80% of lung cancers. A diminished expression level of PAI-2 was significantly correlated with lymph node metastasis and a poor prognosis. The expression of PAI-2 may be useful as a marker for evaluating the prognosis of lung cancer.\n3) Using monoclonal antibodies against cytokeratin (CK) and a novel immunohistochemical method for the detection of CK positive tumor cells, we examined disseminated tumor cells in the bone marrow and lymph nodes of primary lung cancer patients. Lymphatic micrometastases and bone marrow micrometastases were detected in 27.3% and 23.5% of lung cancer patients, respectively. After revised staging based on the sites of nodal micrometastases, patients with stage II or stage IIIA disease showed significantly poorer survival rates than those with stage I disease. A significant correlation was found between the reduced E-cadherin expression in primary sites and nodal micrometastases.\n4) In lung cancer tissue samples, the expression of VEGF mRNA was found at a high rate independent of histological subtypes. Among the four splicing variants, VEGF121 and 165 were the dominant types. As a marker of tumor angiogenesis, the VEGF expression level may be a significant prognostic indicator of lung cancers in early stages.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:08407039, 研究期間(年度):1996 – 1998","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「肺癌における腫瘍特性および宿主要因の分子生物学的総合解析」課題番号08407039\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-08407039/084070391998kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00066080","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20019897"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20019897","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-08407039/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-08407039/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-08407039/084070391998kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-08407039/084070391998kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-30"}],"displaytype":"detail","filename":"ME-PR-WATANABE-Y-kaken 1999-3p.pdf","filesize":[{"value":"173.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WATANABE-Y-kaken 1999-3p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/59829/files/ME-PR-WATANABE-Y-kaken 1999-3p.pdf"},"version_id":"b99efbb3-2ceb-4ea1-b872-bb606d79c4f2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肺癌における腫瘍特性および宿主要因の分子生物学的総合解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺癌における腫瘍特性および宿主要因の分子生物学的総合解析"},{"subitem_title":"The molecular-biological overall analysis of tumor characteristics and host factor in primary lung cancer.","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2835"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-30"},"publish_date":"2022-05-30","publish_status":"0","recid":"59829","relation_version_is_last":true,"title":["肺癌における腫瘍特性および宿主要因の分子生物学的総合解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:59:59.643443+00:00"}