{"created":"2023-07-27T07:00:08.055059+00:00","id":59953,"links":{},"metadata":{"_buckets":{"deposit":"9b048302-e888-422b-bae1-d7398a0b76f1"},"_deposit":{"created_by":18,"id":"59953","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"59953"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00059953","sets":["2812:2813:2838"]},"author_link":["105628"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1995","bibliographic_titles":[{"bibliographic_title":"平成7(1995)年度 科学研究費補助金 重点領域研究 研究概要"},{"bibliographic_title":"1995 Research Project Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tatsuka, Masaaki"}],"nameIdentifiers":[{"nameIdentifier":"105628","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50216991","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50216991"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1.G0/G1細胞周期の進行に重要な役割を担っている機能分子群のひとつ、4型サイクリン依存的キナーゼ(Cdk4)の恒常的活性型変異体(constitutively active form)遺伝子を哺乳類細胞に強制発現することによって、紫外線ならびにX線誘発G1進行阻害効果が起こらないことを見い出した。G1阻害のかからなくなった細胞株では、紫外線誘発染色分体異常の頻度が上昇した。また、X線誘発の染色分体ならびに染色体異常の頻度についても、コントロールの細胞群と比較して、高いことがわかった。\n2.細胞周期進行のチェックポイントを制御する機構を構成するような新たな因子を検索した。その結果、酵母のチェックポイント欠損変異株、chkの表現形質を相補する哺乳類細胞の遺伝子として、新たな候補遺伝子を単離した。この遺伝子は酵母の分裂異常多発変異株、iplを相補する酵母遺伝子iplと相同性を認めた。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:07272237, 研究期間(年度):1995","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「哺乳類の細胞周期進行モニターにおける制御異常と発がん感受性」課題番号07272237\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07272237/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00066204","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50216991"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50216991","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07272237/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07272237/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"達家, 雅明"}],"nameIdentifiers":[{"nameIdentifier":"105628","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50216991","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50216991"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-06"}],"displaytype":"detail","filename":"CA-PR-TATSUKA-M-kaken 2016-2p.pdf","filesize":[{"value":"111.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TATSUKA-M-kaken 2016-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/59953/files/CA-PR-TATSUKA-M-kaken 2016-2p.pdf"},"version_id":"d64299a4-532c-4ab1-8a11-4b024c094e48"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"哺乳類の細胞周期進行モニターにおける制御異常と発がん感受性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"哺乳類の細胞周期進行モニターにおける制御異常と発がん感受性"}]},"item_type_id":"9","owner":"18","path":["2838"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-06-06"},"publish_date":"2022-06-06","publish_status":"0","recid":"59953","relation_version_is_last":true,"title":["哺乳類の細胞周期進行モニターにおける制御異常と発がん感受性"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T06:40:55.881865+00:00"}