{"created":"2023-07-27T07:00:11.252223+00:00","id":60024,"links":{},"metadata":{"_buckets":{"deposit":"9c5a6614-277b-49f3-98c0-34610058653e"},"_deposit":{"created_by":18,"id":"60024","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"60024"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00060024","sets":["2812:2813:2838"]},"author_link":["26985"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1995","bibliographic_titles":[{"bibliographic_title":"平成7(1995)年度 科学研究費補助金 一般研究(C) 研究概要"},{"bibliographic_title":"1995 Research Project Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ネパール産生薬Emberia ribes(現地名 Bayubidanga)の果実は,古来,条虫駆除の目的に用いられてきたが,近年ネパールの研究者らによって,ヒト鞭虫に有効であると報告された.しかし,同様の投与実験がスリランカで行われた結果,その効果は疑わしいと報告され,現在未解決となっている.我々は,既にE.ribesの果実成分中ネズミ鞭虫(Trichuris muris)に対して強い殺鞭虫作用を示す物質がembelin(1)であることを明かとした(MLC=0.01mg/ml).しかし,UV吸収による追跡によって本化合物は煎剤中には役1/10量が移行するのみで,水と煮沸すると別種の化合物に変化することが明かとなった.この変化体として化合物2(45%),化合物3(10%),化合物4(2.3%),化合物5(3.3%)の4種を分離し,うち化合物2,化合物3の2種の構造を明かとした.化合物2はembelinが脱水を伴いつつその骨格が二量化したもの“dimer\"で,化合物3はそれが更に脱水閉環し,還元をうけ“benzofuran-quinone\"となったものであった.また,我々が新しく製したpotassium embelateは水と煮沸しても安定であった.上記のような変化は,従来天然成分の変化として考えられてきた抱合,加水分解,酸化等とは全く別種のものであり,今後生薬より煎剤を製する際に考慮すべき問題である.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:07672263, 研究期間(年度):1995","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「煎剤調整時における成分変化:ネパール産生薬成分Embelinの化学的変化」課題番号07672263\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672263/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学薬学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00066275","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40077508"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40077508","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672263/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672263/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"津田, 喜典"}],"nameIdentifiers":[{"nameIdentifier":"26985","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40077508","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40077508"},{"nameIdentifier":"40077508","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040077508"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-06"}],"displaytype":"detail","filename":"PH-PR-TSUDA-Y-kaken 2016-2p.pdf","filesize":[{"value":"136.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-TSUDA-Y-kaken 2016-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/60024/files/PH-PR-TSUDA-Y-kaken 2016-2p.pdf"},"version_id":"efe3d26f-8a30-4aa6-b737-8be7c6f29612"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"煎剤調整時における成分変化:ネパール産生薬成分Embelinの化学的変化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"煎剤調整時における成分変化:ネパール産生薬成分Embelinの化学的変化"}]},"item_type_id":"9","owner":"18","path":["2838"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-06-06"},"publish_date":"2022-06-06","publish_status":"0","recid":"60024","relation_version_is_last":true,"title":["煎剤調整時における成分変化:ネパール産生薬成分Embelinの化学的変化"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T06:41:09.269218+00:00"}