{"created":"2023-07-27T07:00:28.465109+00:00","id":60417,"links":{},"metadata":{"_buckets":{"deposit":"738b1aca-1d40-4def-8907-2e14e2c841bf"},"_deposit":{"created_by":18,"id":"60417","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"60417"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00060417","sets":["2812:2813:2838"]},"author_link":["42"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-03-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3p.","bibliographicVolumeNumber":"1993 – 1995","bibliographic_titles":[{"bibliographic_title":"平成7(1995)年度 科学研究費補助金 試験研究(B) 研究成果報告書概要"},{"bibliographic_title":"1995 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"3年度(平成5〜7年度)に渡る研究を通し、得られた新知見等の成果の概要を箇条書すれば以下のようである。\n1.無侵襲・無拘束循環動態モニタシステムの基本設計と開発:(1)無侵襲計測法の検討;本システムの開発に当り、その基本となる無侵襲計測法として、血圧(BP)計測では、その精度と信頼性等に優れた光電的容積振動法を、また心拍出量(CO)計測では生体組織の電気的物性の違いを利用した胸部アドミタンス法を採用し、各々の超小型化を図った電気制御回路を開発した。特に、生体アドミタンス計測では、従来法とは異なる4電極交流(50kHz)電圧クランプ法を考案し、回路の大幅な縮小が実現された。更に、BPやCO値を決定するに当り、CPUによる信号処理を高精度・高信頼に実行するアルゴリズムも開発した。(2)システムの基本設計と試作開発;以上の知見に基づき、電気的アドミタンス法と容積振動法を併用した小型軽量(104x64x32mm,160g)の循環動態モニタ用携帯システムの設計・試作開発に成功した。本システムによれば、BP、CO以外に末梢循環抵抗や心臓酸素消費量指標等の全8項目が長時間同時モニタできる。(3)姿勢情報を含むシステムの基本設計と試作開発;循環生理情報が姿勢・行動変化に大きく影響を与えることに注目し、日常生活の姿勢変化を長時間モニタできるタバコ大サイズの携帯ユニットを設計開発し、前記システムと組合わせた無拘束循環動態・姿勢計測システムの開発に成功した。\n2.システムの試用と性能評価:1.で得たシステムを先ず実際に日常生活場での予備試験的に試用し、システム評価を行ったところ、中強度の運動時や急激な体位変換時等では、ア-ティファクトにより計測困難な場合があったが、全体として安定で信頼できる動作性能を有していた。更に、COの長時間計測の追随性と信頼性を検証するため、侵襲的長時間連続測定装置(Baxter社Vigilance)との対比試験も行い、本法の優位性が実証された。\n3.長時間モニタとデータ解析:以上の所見から、本システムを健常者や院内或は通院している循環器疾患加療患者を対象に24時間以上のモニタリング試験を実施した。得られた長時間時系列データに対し、最大エントロピ法(MEM)解析を適用し、日常行動と非行動による各種循環パラメータの周期構造に及ぼす影響、投薬加療に伴う主に血圧の周期構造に与える影響、夜間血圧低下の心機能性或は末梢循環性因子の寄与度、実験室及び日常生活における血圧昇圧機序の状況恒常性と固体恒常性の関連性など、心理生理学的、循環生理学的並びに臨床生理学的な興味ある新知見を得た。\n4.総合評価と実用化への検討:一連の開発研究とシステム試用の実験的検討を通して、本研究は当初の目標をほぼ達成し、またシステムの有用性と実用性が立証出来たと言える。現在、本研究で考案・開発したシステムについて、メーカーによる製品実用化が検討されており、本研究成果はその基礎資料として期待されている。","subitem_description_type":"Abstract"},{"subitem_description":"In recognition of the increasing need for health maintenance and disease prevention, an attempt was made to develop a non-invasive and ambulatory system capable of monitoring various cardiovascular parameters, naturally including cardiac output and blood pressure, during daily activities in a fully automatic manner. It is based on the electrical admittance cardiography and the volume-oscillometric method. The system mainly consists of (i) a finger cuff with a photo-plethysmographic sensor for detecting blood volume changes and tetra-polar electrodes for detecting the bio-admittance signal, (ii) a portable unit (104x64x32mm, 160g) which allows necessary measuring procedures and control, together with signal processing and data storage in a CMOS RAM,using a single-chip microcomputer, and (iii) data reproducing and analysing unit using a personal computer system. Asubject carries the former two during monitoring Long-term monitoring is made with a desired interval of 2,5 and 10 min preset, and after the monitoring the stored data are reproduced and analyzed by the computer, being displayd pulse rate (HR), pulse interval (PI), systolic (SBP)/meanMBP)/diastolic pressure (DBP), ventricular ejection time (Ts), stroke volume (SV), cardiac output (CO=HR・SV), peripheral vascular resistance (Rp=MBP/CO) and rate pressure product (RPP=HR・SBP) as an index of cardiac oxygen consumption in a trend manner.\nBesides the development of thissystem, a portable instrument for long-term ambulatory monitoring of human posture chnge has been designed, taking physiological importance and usefulness of such information along with cardiovascular haemodynamic parameters into consideration. It is based on the fact that almost all human postures in daily life, e. g. standing, sitting, lying, walking etc., can be estimated from the angles corresponding to the gravitational direction in three portions ; chest, thigh and lower leg. The instrument (58x94x25mm, 130g) includes preamplifiers, an A/D converter (6bit ; sampling interval, 0.1,0.2,0.5,1s), and a CMOS RAM (2MB) for storing the angles from electro-magnetic inclinometers placed on the three portions.\nPerformance, availability and stability for monitoring by these two systems have been tested with successful and satisfactory results. Lots of 24-hour monitorings and data analyzes regarding the interactiive relation among the cardiovascular variables and the periodic construction of their circadian fluctuations using the maximum entropy method (MEM) have also been successfully made, suggesting that each proposed system appears promising as a method for use not only in further advanced basic and clinical cardiovascular researches but also in case of self care at home.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:05555107, 研究期間(年度):1993 – 1995","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「心拍出量・血圧含む循環機能情報の無侵襲・無拘束長時間計測システムの開発」課題番号05555107\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-05555107/055551071995kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学工学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00066665","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40014310"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40014310","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-05555107/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-05555107/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-05555107/055551071995kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-05555107/055551071995kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-01"}],"displaytype":"detail","filename":"TE-PR-YAMAKOSHI-K-kaken 1997-3p.pdf","filesize":[{"value":"163.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"TE-PR-YAMAKOSHI-K-kaken 1997-3p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/60417/files/TE-PR-YAMAKOSHI-K-kaken 1997-3p.pdf"},"version_id":"7d5bcbce-72c2-4f7d-88af-7bfa9af8a1e2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"心拍出量・血圧含む循環機能情報の無侵襲・無拘束長時間計測システムの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心拍出量・血圧含む循環機能情報の無侵襲・無拘束長時間計測システムの開発"},{"subitem_title":"Development of non-invasive and ambulatory monitoring system for cardiovascular haemodynamic parameters inclusive of cardiac output and blood pressure","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2838"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-07-01"},"publish_date":"2022-07-01","publish_status":"0","recid":"60417","relation_version_is_last":true,"title":["心拍出量・血圧含む循環機能情報の無侵襲・無拘束長時間計測システムの開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:42:10.104263+00:00"}