{"created":"2023-07-27T07:00:38.525225+00:00","id":60643,"links":{},"metadata":{"_buckets":{"deposit":"7a1f44fd-4332-46ed-b43f-5d5e5bc4c558"},"_deposit":{"created_by":18,"id":"60643","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"60643"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00060643","sets":["2812:2813:2840"]},"author_link":["26985"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-03-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1992 – 1993","bibliographic_titles":[{"bibliographic_title":"平成5(1993)年度 科学研究費補助金 一般研究(C) 研究成果報告書概要"},{"bibliographic_title":"1993 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ネパール産生薬Bayubidangaは,ヤブコウジ科に属するEmbelia ribesの果実で古来条虫駆除薬として知られているが,最近鞭虫や鉤虫にも有効であると報告されているので,その有効成分を明らかにする目的で本研究を行った.\nE.ribesをエーテルで抽出すると,有効成分として既知のembelinが得られた.一方,熱水で抽出すると別の有効成分としてgallic acidが得られ,embelinが熱水処理によって分解することが示唆された.これら有効成分の活性は,イヌ鞭虫(Trichuris vulpis)に対して,in vitroで,それぞれ0.01mg/ml及び0.5-1mg/mlであった.\nさらに,embelinの沸騰水及びメタノール(有機溶媒)中での分解の様相を明らかとし,熱水との接触によってdimer(二量体)に,メタノール処理ではO-methylembelinに変化することを証明した.\n次いで,embelin及びその誘導体のin vivoの活性をネズミ鞭虫(T.muris)を感染させたマウスを用いて試験した.Hydrocortisone acetate前処理によって感染を成立させたBALB/cマウスに対しては,試験したE.ribes煎剤,embelin,その誘導体のうちpotassium embelateのみが,既知の抗鞭虫薬mebendazoleに匹敵するかなりな効果(治癒率70-100%)を示したが,他は無効であった.一方,predonisolone butylacetate前処理によって感染を成立させたマウス(BALB/c,ICR共)に対しては,potassium embelateもmabendazoleも無効であり,感染の方法が後投与の薬物の効果に大きく影響を与えることが示唆された.これに反して,ivermectinは全てのマウスに有効であった.","subitem_description_type":"Abstract"},{"subitem_description":"A nepali traditional medicine \"Bayubidanga\", fruits of Embelia ribes (a family of Myrsinaceae), has been known to be effective to tapeworms. Since the medicine is reported to be also effective to whipworms and Ascaris, our work was undertaken to clarify what constituent(s) is responsible to this activity.\nExtraction of E.ribes with ether gave known constituent, embelin, as an active principle, while extraction with hot water resulted in another active principle, gallic acid, suggesting that embelin was decomposed into different compound(s) on contact with hot water. In vitro activities of these principles were 0.01 mg/ml and 0.5-1 mg/ml to dog whipworm. Trichuris vulpis, respectively.\nThe features of decomposition of embelin in boiling water and in methanol (organic solvant) were clarified that the former treatment yielded a \"dimer\" and the leatter treatment gae O-methyl derivative.\nIn vivo anti-Trichuris activity of embelin and its derivatives was examined using mice infected with T.muris. It was found that, among E.ribes decoction, embelin, and its derivatives, onlyh potassium embelate was effective (70-100%) cure rate), when applied to BALB/c mice pretreated with hydrocortisone acetate before infection. The activity was comparable to the known anti-Trichuris drug, mebendazole. On the other hand, neither potassiumembelate nor mebendazole was effective, when applied to infected mice (both BALB/c and ICR) pretreated with predonisolone butylacetate, suggesting that infection method largely influences on the result of eficacy of medicine. Contrary to these medicines, ivermectin was constantly effective to all mice tested in this investigation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:04670226, 研究期間(年度):1992 – 1993","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ネパール産生薬Embelia ribesの抗鞭虫作用成分に関する研究」課題番号04670226\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-04670226/046702261993kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00066890","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40077508"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40077508","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-04670226/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-04670226/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-04670226/046702261993kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-04670226/046702261993kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"津田, 喜典"}],"nameIdentifiers":[{"nameIdentifier":"26985","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40077508","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40077508"},{"nameIdentifier":"40077508","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040077508"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-28"}],"displaytype":"detail","filename":"ME-PR-TSUDA-Y-kaken 1995-2p.pdf","filesize":[{"value":"88.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TSUDA-Y-kaken 1995-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/60643/files/ME-PR-TSUDA-Y-kaken 1995-2p.pdf"},"version_id":"1d6c5f52-7372-4e80-86d3-79872d3f5a61"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ネパール産生薬Embelia ribesの抗鞭虫作用成分に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ネパール産生薬Embelia ribesの抗鞭虫作用成分に関する研究"},{"subitem_title":"Studies on Anti-Trichuris Constituents of Embelia ribes, A Nepali Traditional Medicine","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2840"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-07-28"},"publish_date":"2022-07-28","publish_status":"0","recid":"60643","relation_version_is_last":true,"title":["ネパール産生薬Embelia ribesの抗鞭虫作用成分に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T06:43:51.043806+00:00"}