{"created":"2023-07-27T07:00:41.367553+00:00","id":60704,"links":{},"metadata":{"_buckets":{"deposit":"6e855a43-0d0f-44b5-8053-5824567b3c23"},"_deposit":{"created_by":18,"id":"60704","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"60704"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00060704","sets":["934:935:936"]},"author_link":["97038","97037","97705","78","106422","106418","86096","94088","97035","80463"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"272","bibliographicPageStart":"262","bibliographicVolumeNumber":"142","bibliographic_titles":[{"bibliographic_title":"Clinical Neurophysiology"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西川, 裕一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"田中, 志信"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective\nThe purpose of this study was to detect specific motor unit (MU) abnormalities in people with amyotrophic lateral sclerosis (ALS) compared to controls using high-density surface electromyography (HD-SEMG).\nMethods\nSixteen people with ALS and 16 control subjects. The participants performed ramp up and sustained contractions at 30% of their maximal voluntary contraction. HD-SEMG signals were recorded in the vastus lateralis muscle and decomposed into individual MU firing behavior using a convolution blind source separation method.\nResults\nIn total, 339 MUs were detected (people with ALS; n=93, control subjects; n=246). People with ALS showed significantly higher mean firing rate, recruitment threshold, coefficient of variation of the MU firing rate, MU firing rate at recruitment, and motoneurons excitability than those of control subjects (p<0.001). The number of MU, MU firing rate, recruitment threshold, and MU firing rate at recruitment were significantly correlated with disease severity (p<0.001). Multivariable analysis revealed that an increased MU firing rate at recruitment was independently associated with ALS.\nConclusions\nThese results suggest increased excitability at recruitment, which is consistent with neurodegeneration results in a compensatory increase in MU activity.\nSignificance\nAbnormal MU firing behavior provides an important physiological index for understanding the pathophysiology of ALS.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Embargo Period 12 months","subitem_description_type":"Other"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学理工研究域フロンティア工学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00066951","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.clinph.2022.06.016","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.sciencedirect.com/journal/clinical-neurophysiology"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/journal/clinical-neurophysiology","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Elsevier (CC-BY-NC-ND)"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11309888","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1388-2457","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishikawa, Yuichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Holobar, Aleš "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Kohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Tetsuya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ueno, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda , Noriaki "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maruyama, Hirofumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Shinobu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hyngstrom, Allison S."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-10-02"}],"displaytype":"detail","filename":"TE-PR-NISHIKAWA-Y-2022.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"TE-PR-NISHIKAWA-Y-2022.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/60704/files/TE-PR-NISHIKAWA-Y-2022.pdf"},"version_id":"30c28ccd-44a5-48da-9bfe-736eb8d9e258"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Detecting motor unit abnormalities in amyotrophic lateral sclerosis using high-density surface EMG","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Detecting motor unit abnormalities in amyotrophic lateral sclerosis using high-density surface EMG"}]},"item_type_id":"4","owner":"18","path":["936"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-09-29"},"publish_date":"2022-09-29","publish_status":"0","recid":"60704","relation_version_is_last":true,"title":["Detecting motor unit abnormalities in amyotrophic lateral sclerosis using high-density surface EMG"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:21:59.914907+00:00"}