{"created":"2023-07-27T07:00:41.457512+00:00","id":60706,"links":{},"metadata":{"_buckets":{"deposit":"064e83b2-df4f-4fd2-8634-61ba938f1efd"},"_deposit":{"created_by":18,"id":"60706","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"60706"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00060706","sets":["934:935:936"]},"author_link":["97038","97037","97705","78","106422","86096","94088","97035","80463"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"19","bibliographicPageStart":"6615","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Sensors"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西川, 裕一"}],"nameIdentifiers":[{"nameIdentifier":"97035","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90644980","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90644980"}]},{"creatorNames":[{"creatorName":"田中, 志信"}],"nameIdentifiers":[{"nameIdentifier":"78","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40242218","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40242218"},{"nameIdentifier":"40242218","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40242218"},{"nameIdentifier":"40242218","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040242218"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The relationship between motor unit (MU) firing behavior and the severity of neurodegeneration in Parkinson’s disease (PD) is not clear. This study aimed to elucidate the association between degeneration with dopaminergic pathways and MU firing behavior in people with PD. Fourteen females with PD (age, 72.6 ± 7.2 years, disease duration, 3.5 ± 2.1 years) were enrolled in this study. All participants performed a submaximal, isometric knee extension ramp-up contraction from 0% to 80% of their maximal voluntary contraction strength. We used high-density surface electromyography with 64 electrodes to record the muscle activity of the vastus lateralis muscle and decomposed the signals with the convolution kernel compensation technique to extract the signals of individual MUs. We calculated the degree of degeneration of the central lesion-specific binding ratio by dopamine transporter single-photon emission computed tomography. The primary, novel results were as follows: (1) moderate-to-strong correlations were observed between the degree of degeneration of the central lesion and MU firing behavior; (2) a moderate correlation was observed between clinical measures of disease severity and MU firing behavior; and (3) the methods of predicting central nervous system degeneration from MU firing behavior abnormalities had a high detection accuracy with an area under the curve >0.83. These findings suggest that abnormalities in MU activity can be used to predict central nervous system degeneration following PD.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学理工研究域フロンティア工学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00066953","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/s21196615","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.mdpi.com/1424-8220/21/19/6615"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/1424-8220/21/19/6615","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.mdpi.com/journal/sensors"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/journal/sensors","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.mdpi.com/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Authors, published by the MDPI"},{"subitem_rights":"This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1424-8220","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishikawa, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"97035","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90644980","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90644980"}]},{"creatorNames":[{"creatorName":"Watanabe, Kohei"}],"nameIdentifiers":[{"nameIdentifier":"86096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Holobar, Aleš "}],"nameIdentifiers":[{"nameIdentifier":"97705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"94088","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00377459","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00377459"}]},{"creatorNames":[{"creatorName":"Maeda , Noriaki "}],"nameIdentifiers":[{"nameIdentifier":"97037","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maruyama, Hirofumi"}],"nameIdentifiers":[{"nameIdentifier":"97038","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Shinobu"}],"nameIdentifiers":[{"nameIdentifier":"80463","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40242218","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40242218"}]},{"creatorNames":[{"creatorName":"Hyngstrom, Allison S."}],"nameIdentifiers":[{"nameIdentifier":"106422","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-25"}],"displaytype":"detail","filename":"TE-PR-NISHIKAWA-Y-21-06615.pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"TE-PR-NISHIKAWA-Y-21-06615.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/60706/files/TE-PR-NISHIKAWA-Y-21-06615.pdf"},"version_id":"8cb9c23b-7135-45cc-af61-0764c1652db9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients"}]},"item_type_id":"4","owner":"18","path":["936"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-07-25"},"publish_date":"2022-07-25","publish_status":"0","recid":"60706","relation_version_is_last":true,"title":["Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-20T06:11:21.269156+00:00"}